炭疽毒素诱导的人工脂质双层膜破裂。
Anthrax toxin-induced rupture of artificial lipid bilayer membranes.
机构信息
Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899-8120, USA.
出版信息
J Chem Phys. 2013 Aug 14;139(6):065101. doi: 10.1063/1.4816467.
Abstract
We demonstrate experimentally that anthrax toxin complexes rupture artificial lipid bilayer membranes when isolated from the blood of infected animals. When the solution pH is temporally acidified to mimic that process in endosomes, recombinant anthrax toxin forms an irreversibly bound complex, which also destabilizes membranes. The results suggest an alternative mechanism for the translocation of anthrax toxin into the cytoplasm.
摘要
我们通过实验证明，炭疽毒素复合物从感染动物的血液中分离出来后会破坏人工脂质双层膜。当溶液 pH 值暂时酸化以模拟内体中的这一过程时，重组炭疽毒素形成一种不可逆结合的复合物，也会使膜不稳定。这些结果为炭疽毒素进入细胞质的转运提供了一种替代机制。
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