College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China.
Cell Immunol. 2013 Jul-Aug;284(1-2):75-83. doi: 10.1016/j.cellimm.2013.07.008. Epub 2013 Jul 27.
Allograft Inflammatory Factor-1 (AIF-1) is a 17kDa cytoplasmic, calcium-binding, inflammation-responsive scaffold protein that is mainly expressed in immunocytes. AIF-1 influences the immune system at several key points and thus modulates inflammatory diseases. AIF-1 boosts the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase (iNOS) and promotes inflammatory cell proliferation and migration. Here we provide an overview of the different pathological processes regulated by AIF-1 mainly including allograft rejection, autoimmune diseases, central nervous system (CNS) injury, vasculopathy and cancer et al.
同种异体炎症因子-1（AIF-1）是一种 17kDa 的细胞质、钙结合、炎症反应性支架蛋白，主要在免疫细胞中表达。AIF-1 在几个关键节点影响免疫系统，从而调节炎症性疾病。AIF-1 可增强细胞因子、趋化因子、诱导型一氧化氮合酶（iNOS）等炎症介质的表达，促进炎症细胞的增殖和迁移。在这里，我们概述了 AIF-1 调节的不同病理过程，主要包括同种异体排斥反应、自身免疫性疾病、中枢神经系统（CNS）损伤、血管病变和癌症等。
