Shelton Don J, Kirwan C Brock
Brigham Young University, Department of Psychology, United States.
Behav Brain Res. 2013 Nov 1;256:20-6. doi: 10.1016/j.bbr.2013.08.016. Epub 2013 Aug 12.
Pattern separation is a mechanism for encoding memories, whereby distinct memory representations are created for very similar stimuli and events. It has been proposed that depression negatively impacts pattern separation abilities. However, a link between depression and performance in memory tasks requiring pattern separation is still unclear even though it is well established that depression is associated with reduced declarative memory performance and decreased hippocampal volume. Accordingly, we designed a study to investigate the relationship between pattern separation performance and the severity of depression symptoms in an otherwise healthy population. Participants completed a pattern separation memory test and a set of questionnaires to gauge their level of depression. We found a negative relationship between depression scores and pattern separation scores. These results provide support for the idea that depression is negatively related to pattern separation performance.
模式分离是一种记忆编码机制，通过该机制可以为非常相似的刺激和事件创建不同的记忆表征。有人提出，抑郁症会对模式分离能力产生负面影响。然而，尽管抑郁症与陈述性记忆表现下降和海马体体积减小密切相关，但抑郁症与需要模式分离的记忆任务表现之间的联系仍不明确。因此，我们设计了一项研究，以调查在其他方面健康的人群中模式分离表现与抑郁症状严重程度之间的关系。参与者完成了一项模式分离记忆测试和一组问卷，以评估他们的抑郁程度。我们发现抑郁评分与模式分离评分之间存在负相关关系。这些结果支持了抑郁症与模式分离表现呈负相关的观点。
