MicroNano System Research Center, Taiyuan University of Technology, Taiyuan, Shanxi 030024, People's Republic of China; Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education, Taiyuan University of Technology, Taiyuan, Shanxi 030024, People's Republic of China.
Biosens Bioelectron. 2014 Jan 15;51:124-35. doi: 10.1016/j.bios.2013.07.033. Epub 2013 Jul 29.
Surface stress-based biosensors, as one kind of label-free biosensors, have attracted lots of attention in the process of information gathering and measurement for the biological, chemical and medical application with the development of technology and society. This kind of biosensors offers many advantages such as short response time (less than milliseconds) and a typical sensitivity at nanogram, picoliter, femtojoule and attomolar level. Furthermore, it simplifies sample preparation and testing procedures. In this work, progress made towards the use of surface stress-based biosensors for achieving better performance is critically reviewed, including our recent achievement, the optimally circular membrane-based biosensors and biosensor array. The further scientific and technological challenges in this field are also summarized. Critical remark and future steps towards the ultimate surface stress-based biosensors are addressed.
基于表面应力的生物传感器作为一种无标记生物传感器，在技术和社会的发展过程中，在生物、化学和医学应用的信息收集和测量方面引起了广泛关注。这种生物传感器具有许多优点，例如短的响应时间（小于毫秒）和纳克、皮升、飞焦和阿托摩尔级的典型灵敏度。此外，它简化了样品制备和测试程序。在这项工作中，批判性地回顾了在使用基于表面应力的生物传感器以实现更好性能方面取得的进展，包括我们最近的成就，即优化的基于圆形膜的生物传感器和生物传感器阵列。还总结了该领域进一步的科学和技术挑战。针对最终的基于表面应力的生物传感器提出了关键评论和未来步骤。
