Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.
Cancer Cell. 2013 Aug 12;24(2):147-9. doi: 10.1016/j.ccr.2013.07.017.
The master regulator of the classical cytoprotective "heat shock" response, heat shock factor 1 (HSF1), is increasingly implicated in cancer pathogenesis, but the mechanisms remain poorly understood. A recent study connects increased protein translation to activation of HSF1 in malignant cells and demonstrates the therapeutic benefit of targeting this link.
经典细胞保护“热休克”反应的主要调节因子，热休克因子 1（HSF1），越来越多地与癌症发病机制有关，但机制仍知之甚少。最近的一项研究将蛋白质翻译的增加与恶性细胞中 HSF1 的激活联系起来，并证明了靶向这一联系的治疗益处。
