de Billy Emmanuel, Travers Jon, Workman Paul
Oncotarget. 2012 Aug;3(8):741-3. doi: 10.18632/oncotarget.646.
The transcription factor heat shock factor 1 (HSF1) is the master regulator of the heat shock response. It is crucial for cell homeostasis and implicated in aging, neurodegenerative disease and cancer. Although induction by HSF1 of the expression of molecular chaperones and other regulators of protein quality control, both folding and degradation, is well established, the precise and detailed transcriptional network that HSF1 regulates in cancer is poorly understood. An important new study identifies an HSF1-regulated transcriptional program in highly malignant cells that is surprisingly distinct from the traditional heat shock response. The results have significant implications for our molecular understanding of cancer and the development of new therapies.
转录因子热休克因子1（HSF1）是热休克反应的主要调节因子。它对细胞稳态至关重要，并与衰老、神经退行性疾病和癌症有关。尽管HSF1诱导分子伴侣及其他蛋白质质量控制调节因子（包括折叠和降解）的表达已得到充分证实，但HSF1在癌症中调节的精确且详细的转录网络仍知之甚少。一项重要的新研究在高恶性细胞中鉴定出一个HSF1调节的转录程序，该程序出人意料地不同于传统的热休克反应。这些结果对我们在分子层面理解癌症及开发新疗法具有重要意义。
