First Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece.
J Am Coll Cardiol. 2013 Aug 20;62(8):667-76. doi: 10.1016/j.jacc.2013.03.089.
It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase activity as well as enhances the production of reactive oxygen species, thus resulting in diminished nitric oxide bioavailability and the consequent pro-atherogenetic alterations. Important biomarkers of the vasculature are related to endothelial dysfunction, to inflammatory and coagulation processes, and to oxidative stress in DM. Several therapeutic strategies might exert favorable effects on the vasculature of diabetic patients, such as insulin analogues, antihypertensive agents, statins, and hypoglycemic agents, whereas in spite of the prominent role of oxidative stress in diabetes, antioxidant therapy remains controversial. The use of specific biomarkers related to vascular function could be a useful therapeutic approach in such patients.
人们普遍认为，糖尿病（DM）会损害内皮型一氧化氮合酶的活性，同时增强活性氧的产生，从而导致一氧化氮生物利用度降低和随后的促动脉粥样硬化改变。血管的重要生物标志物与内皮功能障碍、炎症和凝血过程以及 DM 中的氧化应激有关。一些治疗策略可能对糖尿病患者的血管产生有利影响，例如胰岛素类似物、抗高血压药物、他汀类药物和降糖药物，而尽管氧化应激在糖尿病中起着重要作用，抗氧化治疗仍然存在争议。使用与血管功能相关的特定生物标志物可能是此类患者的一种有用的治疗方法。
