Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, China.
J Alzheimers Dis. 2013;37(3):495-505. doi: 10.3233/JAD-130641.
Recent evidence implicated aberrant mammalian target of rapamycin (mTOR)-dependent signaling in both Alzheimer's disease (AD) and brain tumors. This review focuses on the potential mechanisms shared by both neurodegeneration and carcinogenesis. In particular, attention was paid to the possible roles of mTOR-dependent signaling in these two fundamental pathophysiological processes. We hypothesize that common stresses could lead either to progressive degeneration or uncontrolled carcinogenesis via cell type specific upregulation of mTOR-dependent signaling in the central nervous system while mTOR-mediated carcinogenesis might permit glial cells to escape from degeneration.
最近的证据表明，异常的哺乳动物雷帕霉素靶蛋白（mTOR）依赖性信号通路与阿尔茨海默病（AD）和脑肿瘤都有关。本综述重点关注神经退行性变和癌发生之间可能存在的共同机制。特别关注了 mTOR 依赖性信号通路在这两个基本病理生理过程中的可能作用。我们假设，共同的应激可能导致中枢神经系统中 mTOR 依赖性信号通路的细胞类型特异性上调，从而导致进行性退化或失控性癌发生，而 mTOR 介导的癌发生可能使神经胶质细胞逃避退化。
