Department of Neuroscience, Institute of Psychiatry, King's College London, London, United Kingdom.
J Alzheimers Dis. 2014;38(1):11-38. doi: 10.3233/JAD-131004.
Alterations in hippocampal neurogenesis have been recognized as an integral part of Alzheimer's disease. Adult hippocampal neurogenesis is regulated by intrinsic and extrinsic factors; one of them is diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis studies in Alzheimer's disease and focuses on the role of diet. The review highlights some of the key dietary compounds and interventions such as calorie restriction, fat, polyphenols, zinc, folate, alcohol and thiamine, and emphasizes the pathways that they modify.
海马体神经发生的改变已被认为是阿尔茨海默病的一个组成部分。成年海马体神经发生受内在和外在因素的调节；其中之一是饮食。本综述评估了阿尔茨海默病中海马体神经发生研究领域的现状，并重点介绍了饮食的作用。该综述强调了一些关键的饮食化合物和干预措施，如热量限制、脂肪、多酚、锌、叶酸、酒精和硫胺素，并强调了它们改变的途径。
