脐带血单个核细胞治疗多系统萎缩的初步结果：三例报告
Preliminary results of cord blood mononuclear cell therapy for multiple system atrophy: a report of three cases.
作者信息
Wu Shu-Hui, Yang Hai-Xin, Jiang Gui-Hua, Gong Dian-Rong, Wang Le-Xin
机构信息
Department of Neurology, Liaocheng People's Hospital of Taishan Medical University, Liaocheng, PR China.
出版信息
Med Princ Pract. 2014;23(3):282-5. doi: 10.1159/000354051. Epub 2013 Aug 13.
OBJECTIVES
This study was designed to evaluate the effects of cord blood mononuclear cell transplantation in multiple system atrophy (MSA).
CLINICAL PRESENTATION AND INTERVENTION
Cord blood mononuclear cells (1-2 × 10(8) cells/6 ml) were injected into the subarachnoid space using lumbar puncture in patients 1 and 2 and cisterna magna puncture in patient 3 in the 3 patients with MSA. The cord blood mononuclear cell transplantation was repeated 30 days after the first treatment in patients 1 and 2; it was repeated twice in patient 3. The clinical outcomes of treatment were used to assess the Unified Multiple System Atrophy Rating Scale (UMSARS) before, 90 and 180 days after the cell transplantation. There were no clinically noticeable side effects from the cord blood mononuclear cells. The UMSARS scores improved after 90 days of the cord blood mononuclear cell therapy in all 3 patients, the most significant improvement being that in urinary incontinence and ability to walk.
CONCLUSIONS
Cord blood mononuclear cell transplantation was safe and potentially effective in the treatment of MSA in the 3 patients.
目的
本研究旨在评估脐血单个核细胞移植治疗多系统萎缩（MSA）的效果。
临床表现与干预
对3例多系统萎缩患者进行治疗，患者1和患者2采用腰椎穿刺将脐血单个核细胞（1 - 2×10⁸细胞/6 ml）注入蛛网膜下腔，患者3采用枕大池穿刺注入。患者1和患者2在首次治疗30天后重复脐血单个核细胞移植；患者3重复进行了两次。在细胞移植前、移植后90天和180天，使用统一多系统萎缩评定量表（UMSARS）评估治疗的临床结果。脐血单个核细胞未产生临床上明显的副作用。所有3例患者在接受脐血单个核细胞治疗90天后UMSARS评分均有所改善，其中尿失禁和行走能力的改善最为显著。
结论
脐血单个核细胞移植治疗这3例多系统萎缩患者是安全的，且可能有效。
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