Parkinson's Disease Research Clinic, Ageing Brain Centre, Brain & Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia.
J Geriatr Psychiatry Neurol. 2010 Jun;23(2):131-7. doi: 10.1177/0891988709358591. Epub 2010 Jan 25.
Parkinson disease (PD) is commonly conceptualized as a movement disorder. Most previous attempts to define the heterogeneity of the condition have used prospective methods based on arbitrary features such as motor symptoms or age of disease onset. However, nonmotor symptoms including neuropsychological, neuropsychiatric, and behavioral impairments have received less attention. Sleep disturbances are extremely common in PD and appear to be associated with cognitive and psychiatric problems. Recent research has begun to elucidate the links between these variables, but the origin and extent of these relationships are not clearly understood. This review outlines the importance of sleep for healthy cognition and mood, highlighting the possible implications that disturbed sleep may have with regard to patients with PD. It also emphasizes the need for further studies that explore the heterogeneity of all disease features in PD.
帕金森病（PD）通常被认为是一种运动障碍。以前大多数试图定义该病症异质性的尝试都使用了基于运动症状或疾病发病年龄等任意特征的前瞻性方法。然而，包括神经心理学、神经精神病学和行为障碍在内的非运动症状却没有得到足够的重视。睡眠障碍在 PD 中极为常见，且似乎与认知和精神问题有关。最近的研究开始阐明这些变量之间的联系，但这些关系的起源和程度尚不清楚。本综述概述了睡眠对健康认知和情绪的重要性，强调了睡眠障碍可能对 PD 患者产生的潜在影响。它还强调了需要进一步研究探索 PD 中所有疾病特征的异质性。
