Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Republic of Korea.
NeuroRehabilitation. 2013;33(3):465-71. doi: 10.3233/NRE-130979.
Many diffusion tensor imaging (DTI) studies have reported an association between cingulum injury and cognition in patients with traumatic brain injury (TBI) using DTI parameters. In this study, we attempted to investigate the relation between cingulum injury and cognition in chronic patients with TBI, using the integrity of the cingulum as well as DTI parameters.
Thirty five consecutive chronic patients with TBI were recruited. The intelligence quotient (IQ) of the Wechsler Intelligence Scale and Memory Assessment Scale (MAS) was used for assessment of cognition. The patients were classified into three groups, according to continuity to the lower portion of the genu of the corpus callosum: type A-both sides of the cingulum showed intact continuity, type B-either cingulum showed a discontinuation, and, type C-both cingulums showed discontinuation. We measured the fractional anisotropy (FA), apparent diffusion coefficient (ADC), and voxel number of both cingulums.
The IQ and MAS scores of type A and B were significantly higher than those of type C, respectively (p < 0.05), however, we did not observe a significant difference between type A and type B (p > 0.05). A positive correlation was observed between the FA value of the cingulum, and IQ and MAS, respectively (IQ r = 0.373, p < 0.05, MAS r = 0.357, p < 0.05), and between the voxel number and MAS (r = 0.500, p < 0.05). By contrast, we observed a negative correlation between the ADC value and IQ (r = -0.353, p < 0.05).
In terms of integrity to the basal forebrain and DTI parameters of the injured cingulum, DTI findings showed a close association with whole cognition and memory in chronic patients with TBI.
许多弥散张量成像（DTI）研究报告称，创伤性脑损伤（TBI）患者的胼胝体损伤与认知功能有关，使用 DTI 参数。在这项研究中，我们试图通过胼胝体损伤的完整性以及 DTI 参数来研究慢性 TBI 患者胼胝体损伤与认知功能的关系。
连续招募了 35 名慢性 TBI 患者。使用韦氏智力量表和记忆评估量表（MAS）的智商（IQ）来评估认知能力。根据胼胝体膝部下段的连续性，将患者分为三组：A 型-两侧胼胝体均显示连续，B 型-一侧胼胝体中断，C 型-两侧胼胝体均中断。我们测量了双侧胼胝体的分数各向异性（FA）、表观扩散系数（ADC）和体素数。
A 型和 B 型的 IQ 和 MAS 评分均明显高于 C 型（p < 0.05），但 A 型与 B 型之间无显著差异（p > 0.05）。胼胝体 FA 值与 IQ 和 MAS 呈正相关（IQ r = 0.373，p < 0.05，MAS r = 0.357，p < 0.05），与体素数与 MAS 呈正相关（r = 0.500，p < 0.05）。相反，我们观察到 ADC 值与 IQ 呈负相关（r = -0.353，p < 0.05）。
就基底前脑的完整性和损伤胼胝体的 DTI 参数而言，DTI 发现与慢性 TBI 患者的整体认知和记忆密切相关。
