Wilde Elisabeth A, Ramos Marco A, Yallampalli Ragini, Bigler Erin D, McCauley Stephen R, Chu Zili, Wu Trevor C, Hanten Gerri, Scheibel Randall S, Li Xiaoqi, Vásquez Ana C, Hunter Jill V, Levin Harvey S
Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas-Houston Medical School, Houston, Texas 77030, USA.
Dev Neuropsychol. 2010;35(3):333-51. doi: 10.1080/87565641003696940.
Structural damage to the prefrontal-cingulate network has been implicated in cognitive and neurobehavioral deficits associated with traumatic brain injury (TBI). Forty-six children who had sustained moderate-to-severe TBI and 43 children with extracranial injury were imaged using diffusion tensor imaging (DTI). Decreased fractional anisotropy (FA) and increased apparent diffusion coefficient (ADC) values were found in the cingulum bundles bilaterally in the TBI group. Cingulum ADC was related to frontal lesion volume, injury severity, and injury mechanism. Finally, cingulum DTI parameters were related to cognitive control measures. DTI detects TBI-related injury to the cingulum, which may facilitate advances in assessment and treatment.
前额叶-扣带网络的结构损伤与创伤性脑损伤（TBI）相关的认知和神经行为缺陷有关。对46名中度至重度TBI患儿和43名颅外损伤患儿进行了扩散张量成像（DTI）检查。在TBI组双侧扣带束中发现分数各向异性（FA）降低和表观扩散系数（ADC）值增加。扣带束ADC与额叶病变体积、损伤严重程度和损伤机制有关。最后，扣带束DTI参数与认知控制测量有关。DTI可检测出与TBI相关的扣带束损伤，这可能有助于评估和治疗方面的进展。
