Italiano Domenico, Bramanti Placido, Militi David, Mondello Stefania, Calabro Rocco Salvatore
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy,
Eur J Pediatr. 2014 Dec;173(12):1585-6. doi: 10.1007/s00431-013-2138-9. Epub 2013 Aug 16.
Nocturnal bruxism is a common oromandibular movement disorder highly prevalent in children, but its pathophysiological mechanism has not been fully explained. Iatrogenic sleep bruxism has been described following treatment with several psychotropic medications. However, no case of antihistamine-induced bruxism has been reported to date. Herein, we describe a 4-year-old child who experienced nocturnal bruxism during treatment for bronchospasm and rhinitis with the antihistamine ketotifen. Drug rechallenge was also performed.
The present case adds useful information to our knowledge of bruxism. Complex and poorly understood interactions between multiple central nervous system neurotransmitters, such as histamine, serotonin, and dopamine, are involved.
夜间磨牙症是一种常见的口颌运动障碍，在儿童中高度流行，但其病理生理机制尚未完全阐明。几种精神药物治疗后曾有医源性睡眠磨牙症的报道。然而，迄今为止，尚无抗组胺药诱发磨牙症的病例报告。在此，我们描述一名4岁儿童，在用抗组胺药酮替芬治疗支气管痉挛和鼻炎期间出现夜间磨牙症。还进行了药物激发试验。
本病例为我们对磨牙症的认识增添了有用信息。涉及多种中枢神经系统神经递质（如组胺、5-羟色胺和多巴胺）之间复杂且了解不足的相互作用。
