Javadzadegan Ashkan, Shimizu Yasutomo, Behnia Masud, Ohta Makoto
Mechanical and Mechatronic Engineering, School of Aerospace, The University of Sydney, Sydney, NSW, Australia.
Technol Health Care. 2013;21(4):357-67. doi: 10.3233/THC-130736.
Flow recirculation and shear strain are physiological processes within coronary arteries which are associated with pathogenic biological pathways. Distinct Quite apart from coronary stenosis severity, lesion eccentricity can cause flow recirculation and affect shear strain levels within human coronary arteries.
The aim of this study is to analyse the effect of lesion eccentricity on the transient flow behaviour in a model of a coronary artery and also to investigate the correlation between Reynolds number (Re) and the eccentricity effect on flow behaviour.
A transient particle image velocimetry (PIV) experiment was implemented in two silicone based models with 70% diameter stenosis, one with eccentric stenosis and one with concentric stenosis.
At different times throughout the flow cycle, the eccentric model was always associated with a greater recirculation zone length, maximum shear strain rate and maximum axial velocity; however, the highest and lowest impacts of eccentricity were on the recirculation zone length and maximum shear strain rate, respectively. Analysis of the results revealed a negative correlation between the Reynolds number (Re) and the eccentricity effect on maximum axial velocity, maximum shear strain rate and recirculation zone length.
As Re number increases the eccentricity effect on the flow behavior becomes negligible.
血流再循环和剪切应变是冠状动脉内的生理过程，与致病生物学途径相关。除了冠状动脉狭窄程度外，病变偏心度可导致血流再循环并影响人体冠状动脉内的剪切应变水平。
本研究旨在分析病变偏心度对冠状动脉模型中瞬态血流行为的影响，并研究雷诺数（Re）与偏心度对血流行为影响之间的相关性。
在两个直径狭窄70%的硅基模型中进行了瞬态粒子图像测速（PIV）实验，一个模型为偏心狭窄，另一个为同心狭窄。
在整个血流周期的不同时间，偏心模型总是与更大的再循环区长度、最大剪切应变率和最大轴向速度相关；然而，偏心度对再循环区长度和最大剪切应变率的影响分别最大和最小。结果分析显示，雷诺数（Re）与偏心度对最大轴向速度、最大剪切应变率和再循环区长度的影响之间呈负相关。
随着Re数增加，偏心度对血流行为的影响可忽略不计。
