Xie Xinzhou, Li Yabing, Xie Songyun
Technol Health Care. 2018;26(2):229-238. doi: 10.3233/THC-160529.
Flow recirculation occurs in eccentric coronary stenosis, which can lead to adverse outcome. The complex local geodesic patterns of eccentric stenosis are critical factors in determining the flow characteristics in post-stenotic flow.
The main objective of this study is to relate the relationship between the detailed morphological parameters in eccentric coronary stenosis and the post-stenotic flow characteristics.
Several idealized eccentric coronary stenosis models with variable morphological parameters are created to conduct a series of computational fluid dynamics analysis. The impact of four specific lesion morphological parameters, eccentricity index (EI), diameter stenosis (DS), stenosis length (SL) and shape of lesion, are investigated.
When EI is small (< 0.33), the length of recirculation zones would increase as EI increase; while when EI is large (> 0.33), it would decreased as EI increase; Larger magnitude of retrograde flow occurs in models with smaller EIs. Both the recirculation zone length and maximum shear rate increase significantly as DS increases. Increase of SL will lead to increase of recirculation zone length. Higher maximum shear rate and larger recirculation zone are observed in models with sharper stenosis shape.
Except DS, the detailed geometry patterns (EI, SL and shape of the stenosis) also have great impact on post-stenotic flow behaviors in eccentric coronary stenosis.
偏心性冠状动脉狭窄中会出现血流再循环，这可能导致不良后果。偏心性狭窄复杂的局部测地线模式是决定狭窄后血流特征的关键因素。
本研究的主要目的是探讨偏心性冠状动脉狭窄的详细形态学参数与狭窄后血流特征之间的关系。
创建了几个具有可变形态学参数的理想化偏心性冠状动脉狭窄模型，以进行一系列计算流体动力学分析。研究了四个特定病变形态学参数，即偏心指数（EI）、直径狭窄（DS）、狭窄长度（SL）和病变形状的影响。
当EI较小时（<0.33），随着EI增加，再循环区域的长度会增加；而当EI较大时（>0.33），随着EI增加，再循环区域的长度会减小；在EI较小的模型中会出现更大程度的逆流。随着DS增加，再循环区域长度和最大剪切率均显著增加。SL增加会导致再循环区域长度增加。在狭窄形状更尖锐的模型中观察到更高的最大剪切率和更大的再循环区域。
除DS外，详细的几何模式（EI、SL和狭窄形状）对偏心性冠状动脉狭窄的狭窄后血流行为也有很大影响。
