Tilden M E, Boney R S, Goldenberg M M, Rosenbaum J T
Department of Ophthalmology, Oregon Health Sciences University, Portland.
J Ocul Pharmacol. 1990 Summer;6(2):131-5. doi: 10.1089/jop.1990.6.131.
Topical non-steroidal anti-inflammatory drugs may serve as an alternative or adjunct to topical corticosteroid therapy for iritis. We have tested the efficacy of topically given S(+)-ibuprofen in a rabbit model of uveitis secondary to the intravitreal injection of human recombinant interleukin 1-alpha. Topically administered S(+)-ibuprofen was found to inhibit increased vascular permeability associated with this model. These results with topical S(+)-ibuprofen compare favorably to the results seen with topical prednisolone and are significantly superior to the results seen with topical flurbiprofen. Topical S(+)-ibuprofen did not significantly reduce the cellular infiltration associated with interleukin-1 induced inflammation. These findings suggest a potential role for topical S(+)-ibuprofen in the treatment of ocular inflammation and, in this animal model, it appears to be superior to an alternative non-steroidal compound, but further studies are indicated to assess its activity in alternate models of ocular inflammation.
局部用非甾体抗炎药可作为虹膜炎局部用皮质类固醇治疗的替代或辅助药物。我们已在玻璃体内注射人重组白细胞介素1-α继发葡萄膜炎的兔模型中测试了局部给予S(+)-布洛芬的疗效。发现局部给予S(+)-布洛芬可抑制与该模型相关的血管通透性增加。局部用S(+)-布洛芬的这些结果与局部用泼尼松龙的结果相比更有利，且明显优于局部用氟比洛芬的结果。局部用S(+)-布洛芬并未显著减少与白细胞介素-1诱导的炎症相关的细胞浸润。这些发现提示局部用S(+)-布洛芬在眼部炎症治疗中具有潜在作用，在该动物模型中，它似乎优于另一种非甾体化合物，但需要进一步研究以评估其在其他眼部炎症模型中的活性。
