Williams R N, Paterson C A
Exp Eye Res. 1987 Feb;44(2):191-8. doi: 10.1016/s0014-4835(87)80003-9.
An acute inflammatory response was initiated in the rabbit eye by an intravitreal injection of bacterial endotoxin. We examined the effect of topical corticosteroid therapy upon polymorphonuclear leukocyte (PMN) infiltration into the eye, protein leakage into aqueous humor and ascorbate level in aqueous humor. Corticosteroid therapy initiated prior to injection of endotoxin suppresses the clinical signs of inflammation, partially prevents the fall in aqueous-humor ascorbate level, has little effect upon protein leakage, but markedly reduces PMN infiltration. Corticosteroid therapy initiated after the injection of endotoxin also suppresses the clinical signs of inflammation, reduces the fall in ascorbate levels and does not influence protein leakage. However, in this case there is a marked persistence of PMN infiltration into ocular tissues. Thus the number of PMNs present in the ocular tissues is little different from that in non-steroid treated control eyes, although the clinical signs of inflammation are reduced. We suggest that in the clinical situation, the initial anti-inflammatory activity of the corticosteroids is related to an inhibitory effect upon the activity of PMNs already within the tissues, which then prevents the ensuing cascade of characteristic inflammatory events.
通过玻璃体腔内注射细菌内毒素在兔眼中引发急性炎症反应。我们研究了局部应用皮质类固醇疗法对多形核白细胞（PMN）浸润到眼内、蛋白质渗漏到房水以及房水中抗坏血酸水平的影响。在内毒素注射前开始的皮质类固醇疗法可抑制炎症的临床症状，部分防止房水抗坏血酸水平下降，对蛋白质渗漏影响不大，但显著减少PMN浸润。在内毒素注射后开始的皮质类固醇疗法也可抑制炎症的临床症状，减少抗坏血酸水平下降，且不影响蛋白质渗漏。然而，在这种情况下，PMN向眼组织的浸润明显持续存在。因此，尽管炎症的临床症状有所减轻，但眼组织中存在的PMN数量与未用类固醇治疗的对照眼相比差异不大。我们认为，在临床情况下，皮质类固醇的初始抗炎活性与对组织内已存在的PMN活性的抑制作用有关，这进而阻止了随后一系列典型的炎症事件。
