呈现经尸检证实的额颞叶变性的神经心理学测试图谱。
Presenting neuropsychological testing profile of autopsy-confirmed frontotemporal lobar degeneration.
机构信息
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, N.Y., USA.
出版信息
Dement Geriatr Cogn Disord. 2013;36(5-6):279-89. doi: 10.1159/000353860. Epub 2013 Aug 16.
AIMS
We aimed to investigate how neuropsychological test measures at presentation might differentiate frontotemporal lobar degeneration (FTLD) from Alzheimer's disease (AD).
METHODS
We compared autopsy-confirmed FTLD and definite AD with Clinical Dementia Rating ≤1. Factor scores and t values of each neuropsychological test measure were compared between FTLD and AD patients. Logistic regression analyses were applied to identify independent predictors within test measures for the differentiation of FTLD from AD.
RESULTS
Factor analyses showed that the memory domain was more severely impaired in AD than in FTLD, whereas the language and attention domains were more severely impaired in FTLD than in AD. Multiple logistic regression analysis showed that Letter Fluency, Boston Naming Test and delayed memory recall remained independent predictors of FTLD compared to AD. However, test measures did not discriminate between FTLD-tau and FTLD-ubiquitin.
CONCLUSION
We confirm that memory and language function tests discriminate between FTLD and AD.
目的
本研究旨在探讨发病时的神经心理学测试指标如何区分额颞叶变性（FTLD）和阿尔茨海默病（AD）。
方法
我们比较了经尸检证实的 FTLD 和明确的 AD 患者（临床痴呆评定量表≤1）。比较 FTLD 和 AD 患者之间的神经心理学测试指标的因子得分和 t 值。应用逻辑回归分析确定测试指标中区分 FTLD 和 AD 的独立预测因子。
结果
因子分析显示 AD 患者的记忆域损伤比 FTLD 更严重，而 FTLD 患者的语言和注意力域损伤比 AD 更严重。多因素逻辑回归分析显示，与 AD 相比，字母流畅性、波士顿命名测验和延迟记忆回忆仍然是 FTLD 的独立预测因子。然而，测试指标无法区分 FTLD-tau 和 FTLD-泛素。
结论
我们证实记忆和语言功能测试可区分 FTLD 和 AD。
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