利用光封闭配体进行细胞内 G-四链体基因的光调控下调。
Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand.
机构信息
Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
出版信息
Chem Commun (Camb). 2013 Oct 4;49(76):8453-5. doi: 10.1039/c3cc44737e.
Abstract
The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.
摘要
一种笼状 G-四链体配体的使用允许使用紫外光作为外部触发因素来对含有四链体的基因进行转录控制。一种重要的癌基因 SRC 参与上皮肿瘤的起始和增殖，研究表明，在用笼状配体与紫外光处理协同处理的细胞中，SRC 显著下调。
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