Upadhyay Kiran, Fine Richard N
Division of Pediatric Nephrology, Department of Pediatrics, Stony Brook Long Island Children's Hospital, State University of New York at Stony Brook, Stony Brook, NY, 11794, USA,
Pediatr Nephrol. 2014 Aug;29(8):1337-47. doi: 10.1007/s00467-013-2587-4. Epub 2013 Aug 16.
Hematopoietic stem cell transplantation (HSCT) is an accepted treatment modality for various malignant and non-malignant disorders of the lympho-hematopoietic system. Patient survival rate has increased significantly with the use of this procedure. However, with the increase in disease-free patient survival rates, complications including various organ toxicities are also common. Kidney, liver, lung, heart, and skin are among those solid organs that are commonly affected and frequently lead to organ dysfunction and eventually end-organ disease. Conservative measures may or may not be successful in managing the organ failure in these patients. Solid organ transplantation has been shown to be promising in those patients who fail conservative management. This review will summarize the causes of solid organ (kidney, liver, and lung) dysfunction and the available data on transplantation of these solid organs in post-HSCT recipients.
造血干细胞移植（HSCT）是治疗淋巴造血系统各种恶性和非恶性疾病的一种公认的治疗方式。随着该程序的应用，患者生存率显著提高。然而，随着无病患者生存率的提高，包括各种器官毒性在内的并发症也很常见。肾脏、肝脏、肺、心脏和皮肤是常见受影响的实体器官，常导致器官功能障碍并最终发展为终末期器官疾病。保守措施在管理这些患者的器官衰竭方面可能成功也可能不成功。对于保守治疗失败的患者，实体器官移植已显示出前景。本综述将总结实体器官（肾脏、肝脏和肺）功能障碍的原因以及这些实体器官在HSCT后受者中移植的现有数据。
