中性粒细胞明胶酶相关脂质运载蛋白与急性肾损伤：一个神话的终结？ - Suppr

NGAL and AKI: the end of a myth?

作者信息

Legrand Matthieu, Darmon Michael, Joannidis Michael

机构信息

Department of Anesthesiology and Critical Care and Burn Center, Hôpitaux Universitaires St-Louis-Lariboisièere, APHP, Paris, France.

出版信息

Intensive Care Med. 2013 Oct;39(10):1861-3. doi: 10.1007/s00134-013-3061-2. Epub 2013 Aug 16.

DOI:10.1007/s00134-013-3061-2

PMID:23949705

Abstract

摘要

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NGAL and AKI: the end of a myth?中性粒细胞明胶酶相关脂质运载蛋白与急性肾损伤：一个神话的终结？

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The search for perfect biomarkers in acute kidney damage: the case of NGAL, from AKI to acute pyelonephritis: back to the clinic?急性肾损伤中完美生物标志物的探寻：以中性粒细胞明胶酶相关脂质运载蛋白为例，从急性肾损伤到急性肾盂肾炎：回归临床？

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Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness.危重病患者脓毒症与非脓毒症急性肾损伤患者的血浆和尿液中性粒细胞明胶酶相关载脂蛋白。

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Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis.亚临床和临床急性肾损伤具有相似的尿肽特征和预后。

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Hippokratia. 2014 Jul-Sep;18(3):262-8.

Biomarkers for AKI improve clinical practice: no.急性肾损伤的生物标志物改善临床实践：并非如此。

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本文引用的文献

Intensive Care Med. 2013 Oct;39(10):1714-24. doi: 10.1007/s00134-013-3040-7. Epub 2013 Aug 6.

Clinical review: Predictive value of neutrophil gelatinase-associated lipocalin for acute kidney injury in intensive care patients.临床综述：中性粒细胞明胶酶相关脂质运载蛋白对重症监护患者急性肾损伤的预测价值

Crit Care. 2013 Apr 24;17(2):211. doi: 10.1186/cc11855.

Accuracy of urine NGAL commercial assays in critically ill patients.重症患者尿中性粒细胞明胶酶相关脂质运载蛋白商业检测法的准确性

Intensive Care Med. 2013 Mar;39(3):541-2. doi: 10.1007/s00134-012-2788-5. Epub 2012 Dec 15.

Immunoassays distinguishing between HNL/NGAL released in urine from kidney epithelial cells and neutrophils.免疫测定法区分尿液中肾脏上皮细胞和中性粒细胞释放的 HNL/NGAL。

Clin Chim Acta. 2012 Oct 9;413(19-20):1661-7. doi: 10.1016/j.cca.2012.05.010. Epub 2012 May 18.

Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass.小儿体外循环后尿急性肾损伤生物标志物的时间关系及预测价值。

J Am Coll Cardiol. 2011 Nov 22;58(22):2301-9. doi: 10.1016/j.jacc.2011.08.017.

Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial.血浆中性粒细胞明胶酶相关载脂蛋白在急性心力衰竭患者中的预后价值：NGAL EvaLuation 与 B 型利钠肽在急性失代偿性心力衰竭（GALLANT）试验中的联合研究。

Eur J Heart Fail. 2011 Aug;13(8):846-51. doi: 10.1093/eurjhf/hfr087.

Neutrophil gelatinase-associated lipocalin at ICU admission predicts for acute kidney injury in adult patients.入住 ICU 时中性粒细胞明胶酶相关载脂蛋白预测成人患者急性肾损伤。

Am J Respir Crit Care Med. 2011 Apr 1;183(7):907-14. doi: 10.1164/rccm.200908-1214OC. Epub 2010 Oct 8.

The origin of multiple molecular forms in urine of HNL/NGAL.HNL/NGAL 尿中多种分子形式的起源。

Clin J Am Soc Nephrol. 2010 Dec;5(12):2229-35. doi: 10.2215/CJN.00980110. Epub 2010 Sep 9.

Neutrophil gelatinase-associated lipocalin: a biomarker in COPD.中性粒细胞明胶酶相关脂质运载蛋白：COPD 的生物标志物。

Chest. 2010 Oct;138(4):888-95. doi: 10.1378/chest.09-2718. Epub 2010 May 21.

Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury.中性粒细胞明胶酶相关脂质运载蛋白在伴有和不伴有急性肾损伤的成年脓毒症患者中的研究。

Intensive Care Med. 2010 Aug;36(8):1333-40. doi: 10.1007/s00134-010-1887-4. Epub 2010 Apr 16.

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NGAL and AKI: the end of a myth?

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