Pettoello Mantovani M, Giardino I, Magli A, di Martino L, Guandalini S
Department of Pediatrics, University of Naples, Italy.
J Pediatr Gastroenterol Nutr. 1990 Aug;11(2):196-200. doi: 10.1097/00005176-199008000-00007.
In an ophthalmologic study of 90 children with symptomatic giardiasis, ocular alterations were found in 10. Eight of these subjects presented an extensive "salt and pepper" degeneration of the pigmented epithelium involving 360 degrees of the midperiphery of both eyes. In one of the eight children, the pigmented epithelium showed atrophic areas, and in another there was a small hard exudate in the left eye. Of 2 remaining of the 10 children with ocular alterations, 1 presented with slight decoloration of the temporal half of the optic disc, and the other was affected by chorioretinitis. After single-dose antiprotozoic therapy (tinidazole 50 mg/kg), parasitologic tests were negative in all subjects and remained so throughout a 1-year follow-up. However, the characteristic epithelial lesion remained unaltered in all eight children for the entire follow-up period, as well as the optic disc decoloration in the only observed case. The child affected by chorioretinitis recovered after 3 weeks of combined treatment with bethametasone plus deflazacort. In two control groups, 1 of 200 healthy children and 1 of 200 children with gastrointestinal symptoms but without giardiasis, no case of "salt and pepper" degeneration of the pigmented epithelium or other significant ocular alterations was found.
在一项针对90名有症状贾第虫病患儿的眼科研究中，10名患儿出现眼部病变。其中8名患儿呈现广泛的色素上皮“椒盐样”变性，累及双眼周边部360度范围。这8名患儿中的1名，色素上皮出现萎缩区域，另1名左眼有一小片硬性渗出物。在10名有眼部病变的患儿中，其余2名，1名视盘颞侧半稍有褪色，另1名患有脉络膜视网膜炎。单剂量抗原生动物治疗（替硝唑50mg/kg）后，所有患儿的寄生虫学检测均为阴性，且在1年随访期间一直保持阴性。然而，在整个随访期间，所有8名患儿的特征性上皮病变以及唯一观察病例中的视盘褪色均无变化。患有脉络膜视网膜炎的患儿在倍他米松加地夫可特联合治疗3周后康复。在两个对照组中，200名健康儿童和200名有胃肠道症状但无贾第虫病的儿童中，均未发现色素上皮“椒盐样”变性或其他明显眼部病变的病例。
