Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
Pharmacol Rep. 2013;65(3):756-60. doi: 10.1016/s1734-1140(13)71056-9.
No previous study examined whether statins affect lymphocyte cytokine release in patients with isolated hypertriglyceridemia.
The study included 46 patients with elevated triglyceride levels and peripheral artery stenosis, randomly assigned to receive simvastatin or placebo. Plasma lipids, glucose homeostasis markers, plasma C-reactive protein and lymphocyte cytokine release were measured at baseline and at the end of the treatment.
Ninety-day simvastatin treatment reduced lymphocyte release of TNF-α, interleukin-2 and interferon-γ, which was accompanied by a decrease in plasma C-reactive protein.
The obtained results suggest that statins produce lymphocyte-suppressing and systemic anti-inflammatory effects in patients with isolated hypertriglyceridemia.
以前没有研究检查他汀类药物是否会影响孤立性高甘油三酯血症患者的淋巴细胞细胞因子释放。
该研究纳入了 46 例甘油三酯水平升高和外周动脉狭窄的患者，随机分为辛伐他汀组或安慰剂组。在基线和治疗结束时测量了血脂、血糖稳态标志物、血浆 C 反应蛋白和淋巴细胞细胞因子释放。
90 天的辛伐他汀治疗降低了 TNF-α、白细胞介素-2 和干扰素-γ的淋巴细胞释放，同时血浆 C 反应蛋白降低。
研究结果表明，他汀类药物在孤立性高甘油三酯血症患者中产生抑制淋巴细胞和全身性抗炎作用。
