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本文引用的文献

1
Polymorphisms in HLA-DRB1 gene and the risk of tuberculosis: a meta-analysis of 31 studies.HLA-DRB1基因多态性与结核病风险：31项研究的荟萃分析
Lung. 2015 Apr;193(2):309-18. doi: 10.1007/s00408-015-9692-z. Epub 2015 Feb 18.
2
The IPD and IMGT/HLA database: allele variant databases.国际参与者数据（IPD）和国际免疫遗传学信息系统/HLA数据库：等位基因变异数据库。
Nucleic Acids Res. 2015 Jan;43(Database issue):D423-31. doi: 10.1093/nar/gku1161. Epub 2014 Nov 20.
3
Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.等位基因频率网络2015年更新：HLA表位、杀伤细胞免疫球蛋白样受体以及疾病与HLA药物不良反应关联的新特征
Nucleic Acids Res. 2015 Jan;43(Database issue):D784-8. doi: 10.1093/nar/gku1166. Epub 2014 Nov 20.
4
Tobacco smoking, alcohol drinking, diabetes, low body mass index and the risk of self-reported symptoms of active tuberculosis: individual participant data (IPD) meta-analyses of 72,684 individuals in 14 high tuberculosis burden countries.吸烟、饮酒、糖尿病、低体重指数与自我报告的活动性肺结核症状风险：对14个高结核病负担国家的72684名个体进行的个体参与者数据（IPD）荟萃分析
PLoS One. 2014 May 2;9(5):e96433. doi: 10.1371/journal.pone.0096433. eCollection 2014.
5
Genetic polymorphisms of IFNG and IFNGR1 in association with the risk of pulmonary tuberculosis.干扰素γ（IFNG）和干扰素受体 1（IFNGR1）的遗传多态性与肺结核发病风险的关联。
Gene. 2014 Jun 10;543(1):140-4. doi: 10.1016/j.gene.2014.03.042. Epub 2014 Mar 25.
6
HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in Kazakhstan.哈萨克斯坦耐多药肺结核患者的人类白细胞抗原II类等位基因
Tissue Antigens. 2014 Feb;83(2):106-12. doi: 10.1111/tan.12279. Epub 2014 Jan 7.
7
Nutritional status of adult patients with pulmonary tuberculosis in rural central India and its association with mortality.印度中部农村成年肺结核患者的营养状况及其与死亡率的关联。
PLoS One. 2013 Oct 24;8(10):e77979. doi: 10.1371/journal.pone.0077979. eCollection 2013.
8
Problem drinking as a risk factor for tuberculosis: a propensity score matched analysis of a national survey.酗酒作为结核病的一个风险因素：一项全国性调查的倾向评分匹配分析
BMC Public Health. 2013 Sep 22;13:871. doi: 10.1186/1471-2458-13-871.
9
Tobacco smoking-associated risk for tuberculosis: a case-control study.吸烟与结核病发病风险的病例对照研究。
Int Health. 2010 Sep;2(3):216-22. doi: 10.1016/j.inhe.2010.07.001.
10
Distribution of HLA-A, B and DRB1 alleles in Sahariya tribe of North Central India: an association with pulmonary tuberculosis.印度中北部撒哈拉亚部落的 HLA-A、B 和 DRB1 等位基因分布：与肺结核的关联。
Infect Genet Evol. 2014 Mar;22:175-82. doi: 10.1016/j.meegid.2013.08.019. Epub 2013 Aug 28.

与巴西亚马逊地区人群肺结核相关的HLA - DRB1*04等位基因

Alleles of HLA-DRB1*04 Associated with Pulmonary Tuberculosis in Amazon Brazilian Population.

作者信息

Souza de Lima Dhêmerson, Morishi Ogusku Mauricio, Porto Dos Santos Maisa, de Melo Silva Cláudia Maria, Alves de Almeida Vanessa, Assumpção Antunes Irineide, Boechat Antonio Luiz, Ramasawmy Rajendranath, Sadahiro Aya

机构信息

Programa de Pós-Graduação em Imunologia Básica e Aplicada, Instituto de Ciências Biológicas, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brasil.

Laboratório de Micobacteriologia, Instituto Nacional de Pesquisas da Amazônia (INPA), Manaus, Amazonas, Brasil.

出版信息

PLoS One. 2016 Feb 22;11(2):e0147543. doi: 10.1371/journal.pone.0147543. eCollection 2016.

DOI:10.1371/journal.pone.0147543
PMID:26901036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4764689/
Abstract

Immunogenetic host factors are associated with susceptibility or protection to tuberculosis (TB). Strong associations of HLA class II genes with TB are reported. We analyzed the HLA-DRB104 alleles to identify subtypes associated with pulmonary TB and their interaction with risk factors such as alcohol, smoking, and gender in 316 pulmonary TB patients and 306 healthy individuals from the Brazilian Amazon. The HLA-DRB104 was prevalent in patients with pulmonary TB (p<0.0001; OR = 2.94; 95% CI = 2.12 to 4.08). Direct nucleotide sequencing of DRB1 exon 2 identified nine subtypes of HLA-DRB104. The subtype HLA-DRB104:11:01 (p = 0.0019; OR = 2.23; 95% CI = 1.34 to 3.70) was associated with susceptibility to pulmonary TB while DRB104:07:01 (p<0.0001; OR = 0.02; 95% CI = 0.001 to 0.33) to protection. Notably, the interaction between alcohol and HLA-DRB104:11:01 increased the risk for developing pulmonary TB (p = 0.0001; OR = 51.3; 95% CI = 6.81 to 386). Multibacillary pulmonary TB, the clinical presentation of disease transmission, was strongly associated with interaction to alcohol (p = 0.0026; OR = 11.1; 95% CI = 3.99 to 30.9), HLA-DRB104:11:01 (p = 0.0442; OR = 2.01; 95% CI = 1.03 to 3.93) and DRB104:92 (p = 0.0112; OR = 8.62; 95% CI = 1.63 to 45.5). These results show that HLA-DRB104 are associated with pulmonary TB. Interestingly, three subtypes, DRB104:07:01, DRB104:11:01 and DRB104:92 of the HLA-DRB1*04 could be potential immunogenetic markers that may help to explain mechanisms involved in disease development.

摘要

免疫遗传宿主因素与结核病（TB）的易感性或保护性相关。有报道称HLA II类基因与结核病有很强的关联。我们分析了HLA-DRB104等位基因，以确定与肺结核相关的亚型，以及它们与酒精、吸烟和性别等风险因素在316例肺结核患者和306名来自巴西亚马逊地区的健康个体中的相互作用。HLA-DRB104在肺结核患者中普遍存在（p<0.0001；OR = 2.94；95%CI = 2.12至4.08）。DRB1外显子2的直接核苷酸测序确定了HLA-DRB104的9种亚型。HLA-DRB104:11:01亚型（p = 0.0019；OR = 2.23；95%CI = 1.34至3.70）与肺结核易感性相关，而DRB104:07:01（p<0.0001；OR = 0.02；95%CI = 0.001至0.33）与保护性相关。值得注意的是，酒精与HLA-DRB104:11:01之间的相互作用增加了患肺结核的风险（p = 0.0001；OR = 51.3；95%CI = 6.81至386）。多菌型肺结核，即疾病传播的临床表现，与酒精（p = 0.0026；OR = 11.1；95%CI = 3.99至30.9）、HLA-DRB104:11:01（p = 0.0442；OR = 2.01；95%CI = 1.03至3.93）和DRB104:92（p = 0.0112；OR = 8.62；95%CI = 1.63至45.5）的相互作用密切相关。这些结果表明HLA-DRB104与肺结核相关。有趣的是，HLA-DRB104的三种亚型DRB104:07:01、DRB104:11:01和DRB1*04:92可能是潜在的免疫遗传标记，有助于解释疾病发展过程中的相关机制。