家兔体内（+）-脱氢枞酸的代谢产物
Metabolites of (+)-dehydroabietic acid in rabbits.
作者信息
Matsumoto T, Hayashi N, Ishida T, Asakawa Y
机构信息
Department of Chemistry, Faculty of Sciences, Hiroshima University, Japan.
出版信息
J Pharm Sci. 1990 Jun;79(6):540-7. doi: 10.1002/jps.2600790618.
The seven metabolites of (+)-dehydroabietic acid (DHA) were newly isolated from rabbit urine by liquid chromatography. On the basis of chemical and spectral data their structures were established to be (15S)-8,11.13-abietatrien-16,18-dioic acid, 2 alpha-hydroxy-8,11,13,15-abietatetraen-18-oic acid, (15R)-15,16-dihydroxy-8,11,13-abietatrien-18-oic acid, 2 beta,15-dihydroxy-8,11,13-abietatrien-18-oic acid, (15S)-2 beta,16-dihydroxy-8,11,13-abietatrien-18-oic acid, 2 alpha,15-dihydroxy-8,11,13-abietatrien-18-oic acid, and (15S)-2 alpha,16-dihydroxy-8,11,13-abietatrien-18-oic acid. The possible hydroxylation routes of DHA in rabbits and the difference between the metabolism of DHA in microorganisms and that in rabbits are discussed.
通过液相色谱法从兔尿中首次分离出了（+）-脱氢枞酸（DHA）的七种代谢产物。根据化学和光谱数据确定它们的结构分别为（15S）-8,11,13-枞三烯-16,18-二酸、2α-羟基-8,11,13,15-枞四烯-18-酸、（15R）-15,16-二羟基-8,11,13-枞三烯-18-酸、2β,15-二羟基-8,11,13-枞三烯-18-酸、（15S）-2β,16-二羟基-8,11,13-枞三烯-18-酸、2α,15-二羟基-8,11,13-枞三烯-18-酸和（15S）-2α,16-二羟基-8,11,13-枞三烯-18-酸。文中讨论了DHA在兔体内可能的羟基化途径以及DHA在微生物和兔体内代谢的差异。
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