Chromosomal radiosensitivity of lymphocytes from Alzheimer's disease patients.
作者信息
Tobi S E, Moquet J E, Edwards A A, Lloyd D C, Itzhaki R F
机构信息
Department of Optometry and Vision Sciences, UMIST, Manchester.
出版信息
J Med Genet. 1990 Jul;27(7):437-40. doi: 10.1136/jmg.27.7.437.
Abstract
We have examined chromosome aberrations in gamma irradiated (3 Gy) lymphocytes from five patients with Alzheimer's disease (AD). In each case, the number of dicentrics was significantly higher than the number in irradiated lymphocytes from five age matched normal subjects, the mean value for AD cells being about 25% higher. There was no significant difference in number of acentrics between AD and normal cells. Examination of the number of first, second, and third division metaphases, using fluorescence plus Giemsa staining, indicated that there was no difference in cycling time between AD and normal cells, and that after irradiation both groups showed the same mitotic delay. The similarity of our findings to those of others with irradiated Down's syndrome cells (from adult patients) is discussed.
摘要
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本文引用的文献
1
The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people.
Mutat Res. 1980 Aug;72(3):523-32. doi: 10.1016/0027-5107(80)90123-2.
2
X-ray-induced chromosome aberrations in Down lymphocytes: an explanation of their increased sensitivity.
Environ Mutagen. 1981;3(1):85-9. doi: 10.1002/em.2860030109.
3
Chromosome damage in G0 X-irradiated lymphocytes from patients with hereditary retinoblastoma.
Cancer Res. 1981 Sep;41(9 Pt 1):3635-8.
4
Sister chromatid exchanges and cell cycle kinetics in Alzheimer's disease.
Biol Psychiatry. 1984 Mar;19(3):319-27.
5
Proliferative kinetics and chromosome damage in trisomy 21 lymphocyte cultures exposed to gamma-rays and bleomycin.
Cancer Res. 1984 Apr;44(4):1499-504.
6
Bleomycin-induced chromosomal aberrations in Down's syndrome lymphocytes.
Mutat Res. 1982 Aug;105(1-2):107-13. doi: 10.1016/0165-7992(82)90216-0.
7
Radiosensitivity in alzheimer disease and Parkinson disease.
Lancet. 1983 Feb 26;1(8322):468-9. doi: 10.1016/s0140-6736(83)91461-7.
8
In vitro chromosomal radiosensitivity in "chromosomal breakage syndromes".
Cancer. 1973 Aug;32(2):380-3. doi: 10.1002/1097-0142(197308)32:2<380::aid-cncr2820320214>3.0.co;2-2.
9
No interaction between ultraviolet and X irradiation on chromosome aberrations in cells with trisomy 21.
Nature. 1974 May 31;249(456):448-9. doi: 10.1038/249448a0.
10
In vitro chromosomal radiosensitivity in patients and in carriers with abnormal non-Down's syndrome karyotypes.
Pediatr Res. 1972 May;6(5):514-20. doi: 10.1203/00006450-197205000-00005.
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