Fischman H K, Reisberg B, Albu P, Ferris S H, Rainer J D
Biol Psychiatry. 1984 Mar;19(3):319-27.
Six female outpatients with Alzheimer's disease (AD) along with four female controls of a similar age range were analyzed for sister chromatid exchangers (SCEs), cell cycle kinetics, and sensitivity to mutagens, in lymphocyte cultures. The mean level of SCEs for the AD patients was 11.40 SCEs/metaphase, while that for the controls was 9.12. The difference between the two groups was significant as shown by the Wilcoxon rank-sum test (p = 0.05). Cell cycle was 50% longer both in the AD patients (31.7 hr) and aged controls (31.5 hr) than in normal young adults (21.76 hr). Mitomycin-C (MMC) decreased the mitotic index in AD patients by 35% and in controls by only 12%. MMC also increased the cell cycle duration in AD patients by a greater extent (20%) than it did in the controls (13.5%), and AD cells were more sensitive to the toxic effects of bromodeoxyuridine. What appeared to be chromosomes with prematurely divided centromeres were also observed in AD cells.
对6名患有阿尔茨海默病（AD）的女性门诊患者以及4名年龄范围相似的女性对照者的淋巴细胞培养物进行了分析，检测其姐妹染色单体交换（SCE）、细胞周期动力学以及对诱变剂的敏感性。AD患者的SCE平均水平为11.40次SCE/中期，而对照组为9.12次。如Wilcoxon秩和检验所示，两组之间的差异具有统计学意义（p = 0.05）。AD患者（31.7小时）和老年对照组（31.5小时）的细胞周期均比正常年轻人（21.76小时）长50%。丝裂霉素-C（MMC）使AD患者的有丝分裂指数降低了35%，而对照组仅降低了12%。MMC还使AD患者的细胞周期持续时间延长的幅度（20%）大于对照组（13.5%），并且AD细胞对溴脱氧尿苷的毒性作用更敏感。在AD细胞中还观察到了似乎具有过早分离着丝粒的染色体。
