Smith T A, Neary D, Itzhaki R F
Mutat Res. 1987 Sep;184(2):107-12. doi: 10.1016/0167-8817(87)90066-6.
Lymphocytes from patients with ataxia telangiectasia and Down's syndrome show a greater frequency of chromosome aberrations after ionising radiation than do lymphocytes from normal people. The connection between Down's syndrome and Alzheimer's disease (AD) is well-known. In view of this and of a study showing a greater sensitivity of AD than of normal lymphoblastoid cells to X-irradiation (measured by viability), we have examined repair of AD lymphocytes (hydroxyurea-treated) by measuring [3H]thymidine incorporation after gamma-irradiation. We have found no difference in incorporation between AD and normal lymphocytes from age-matched individuals. However, incorporation decreases with age in gamma-irradiated cells and to a lesser extent in unirradiated cells.
共济失调毛细血管扩张症和唐氏综合征患者的淋巴细胞在受到电离辐射后，其染色体畸变的频率比正常人的淋巴细胞更高。唐氏综合征与阿尔茨海默病（AD）之间的联系是众所周知的。鉴于此以及一项研究表明AD比正常淋巴母细胞对X射线辐射更敏感（通过活力测量），我们通过测量γ射线辐射后[3H]胸腺嘧啶核苷的掺入情况，研究了AD淋巴细胞（经羟基脲处理）的修复情况。我们发现年龄匹配个体的AD淋巴细胞和正常淋巴细胞在掺入方面没有差异。然而，γ射线辐射细胞中的掺入随年龄增长而减少，未辐射细胞中的减少程度较小。
