体外受精结局与高危饮酒者的酒精摄入量：一项随机干预的影响。
In vitro fertilization outcomes and alcohol consumption in at-risk drinkers: the effects of a randomized intervention.
机构信息
Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Am J Addict. 2013 Sep-Oct;22(5):481-5. doi: 10.1111/j.1521-0391.2013.12019.x. Epub 2013 Apr 5.
BACKGROUND AND OBJECTIVES
Women's use of alcohol in pregnancy is associated with an increased risk of fetal loss and birth defects. Also, alcohol use in women decreases the success of infertility treatment, such as in vitro fertilization (IVF). Our goal was to determine if there were differences in IVF outcomes and alcohol use parameters among at-risk drinkers randomized to a brief intervention (BI) versus assessment only (AO).
METHODS
We conducted a randomized controlled trial to determine the effect of BI or AO among at-risk drinkers on IVF. We studied 37 women (AO = 21; BI = 16).
RESULTS
While the BI group had a significantly greater decrease in the number of drinks/drinking day compared to the AO group (p = .04), there were no differences in the likelihood of implantation failure, chemical pregnancy, spontaneous abortion, preterm birth, or live birth.
CONCLUSIONS
BI and AO contributed to a decrease in alcohol use and did not demonstrate differences in IVF outcomes. A larger study may confirm these preliminary findings.
SCIENTIFIC SIGNIFICANCE
Our results will assist care providers in treating alcohol use in pregnancy in an effective way, such that IVF cycles and the chance of pregnancy are optimized.
背景与目的
女性在怀孕期间饮酒会增加胎儿流产和出生缺陷的风险。此外，女性饮酒会降低体外受精（IVF）等不孕治疗的成功率。我们的目标是确定在随机分配至简短干预（BI）组与仅评估（AO）组的有风险饮酒者中，IVF 结局和饮酒参数是否存在差异。
方法
我们开展了一项随机对照试验，以确定 BI 或 AO 对有风险饮酒者 IVF 的影响。我们研究了 37 名女性（AO = 21；BI = 16）。
结果
BI 组与 AO 组相比，饮酒量/饮酒日显著减少（p = 0.04），但植入失败、化学妊娠、自然流产、早产或活产的可能性均无差异。
结论
BI 和 AO 有助于减少饮酒量，但在 IVF 结局方面没有差异。更大规模的研究可能会证实这些初步发现。
科学意义
我们的研究结果将有助于临床医生以有效的方式治疗孕期饮酒问题，从而优化 IVF 周期和妊娠机会。
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