Chang Grace, McNamara Tay K, Orav E John, Koby Danielle, Lavigne Alyson, Ludman Barbara, Vincitorio Nori Ann, Wilkins-Haug Louise
Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Obstet Gynecol. 2005 May;105(5 Pt 1):991-8. doi: 10.1097/01.AOG.0000157109.05453.84.
To test the effectiveness of a brief intervention in the reduction of prenatal alcohol consumption by women when a partner is included.
Randomized trial of a single session brief intervention given by the study nurse or principal investigator for 304 pregnant women and their partners. The women had positive T-ACE (Tolerance, Annoyed, Cut down, Eye-opener, an alcohol screening test) results and were at risk for alcohol consumption while pregnant. All completed initial diagnostic and postpartum interviews.
Fewer than 20% of participants (median 11.5 weeks of gestation) were abstinent at study enrollment, averaging more than 1.5 drinks per episode. Nearly 30% had 2 or more drinks at a time while pregnant. Prenatal alcohol use declined in both the treatment and control groups after study enrollment, based on a 95% follow-up rate. Factors associated with increased prenatal alcohol use after randomization included more years of education, extent of previous alcohol consumption, and temptation to drink in social situations. Brief interventions for prenatal alcohol reduced subsequent consumption most significantly for the women with the highest consumption initially (regression coefficient, b = -0.163, standard error (b) = 0.063, P < .01). Moreover, the effects of the brief intervention were significantly enhanced when a partner participated (b = -0.932, standard error (b) = 0.468), P < .05).
Pregnant women with the highest levels of alcohol use reduced their drinking most after a brief intervention that included their partners. Recommendations include consistent screening for prenatal alcohol use followed by diagnostic assessment when indicated, and if confirmed by other studies, a patient-partner brief intervention for the heaviest drinkers.
检验一种简短干预措施在纳入伴侣的情况下减少孕妇孕期酒精摄入量的有效性。
对304名孕妇及其伴侣进行单节简短干预的随机试验,由研究护士或主要研究者实施干预。这些女性的T-ACE(耐受性、烦恼、减量、眼开启者,一种酒精筛查测试)结果呈阳性,孕期有饮酒风险。所有参与者均完成了初始诊断和产后访谈。
不到20%的参与者(妊娠中位数为11.5周)在研究入组时戒酒,每次饮酒平均超过1.5杯。近30%的女性在孕期一次饮用2杯或更多杯酒。根据95%的随访率,研究入组后治疗组和对照组的孕期酒精使用量均有所下降。随机分组后与孕期酒精使用量增加相关的因素包括受教育年限更长、既往饮酒程度以及社交场合饮酒的诱惑。对孕期酒精使用的简短干预对最初饮酒量最高的女性随后的饮酒量减少最为显著(回归系数,b = -0.163,标准误(b) = 0.063,P <.01)。此外,当伴侣参与时,简短干预的效果显著增强(b = -0.932,标准误(b) = 0.468),P <.05)。
饮酒量最高的孕妇在包括伴侣的简短干预后饮酒量减少最多。建议包括持续筛查孕期酒精使用情况,必要时进行诊断评估,并且如果其他研究证实,对饮酒量最大的患者及其伴侣进行简短干预。