Division of Gastroenterology and Hepatology, Stadtspital Triemli, Zurich, Switzerland; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
J Crohns Colitis. 2014 Mar;8(3):191-9. doi: 10.1016/j.crohns.2013.07.011. Epub 2013 Aug 13.
Hypoxia can induce inflammation in the gastrointestinal tract. However, the impact of hypoxia on the course of inflammatory bowel disease (IBD) is poorly understood. We aimed to evaluate whether flights and/or journeys to regions lying at an altitude of >2000 m above the sea level are associated with flare-ups within 4 weeks of the trip.
IBD patients with at least one flare-up during a 12-month observation period were compared to a group of patients in remission. Both groups completed a questionnaire.
A total of 103 IBD patients were included (43 with Crohn's disease (CD): mean age 39.3 ± 14.6 years; 60 with ulcerative colitis (UC): mean age 40.4 ± 15.1 years). Fifty-two patients with flare-ups were matched to 51 patients in remission. IBD patients experiencing flare-ups had more frequently undertaken flights and/or journeys to regions >2000 m above sea level within four weeks of the flare-up when compared to patients in remission (21/52 [40.4%] vs. 8/51 [15.7%], p=0.005).
Journeys to high altitude regions and/or flights are a risk factor for IBD flare-ups occurring within 4 weeks of travel.
缺氧可诱发胃肠道炎症。然而，缺氧对炎症性肠病（IBD）病程的影响尚未明确。本研究旨在评估海拔 2000 米以上地区的旅行或飞行是否与旅行后 4 周内的疾病发作有关。
我们比较了在 12 个月观察期内至少有一次发作的 IBD 患者与缓解期患者。两组患者均填写了问卷。
共纳入 103 名 IBD 患者（43 名克罗恩病（CD）患者：平均年龄 39.3 ± 14.6 岁；60 名溃疡性结肠炎（UC）患者：平均年龄 40.4 ± 15.1 岁）。52 名发作患者与 51 名缓解患者相匹配。与缓解期患者相比，发作期患者在疾病发作后 4 周内更频繁地进行了海拔 2000 米以上地区的旅行或飞行（21/52 [40.4%] vs. 8/51 [15.7%]，p=0.005）。
前往高海拔地区旅行或飞行是旅行后 4 周内 IBD 发作的危险因素。
