胃癌患者的恶性肿瘤家族史及其与临床病理特征的关系。

Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients.

机构信息

Department of Gastrointestinal Surgery, Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, 67 West Dongchang Road, Liaocheng, Shandong Province 252000, China.

出版信息

World J Surg Oncol. 2013 Aug 16;11(1):201. doi: 10.1186/1477-7819-11-201.

DOI:10.1186/1477-7819-11-201

PMID:23953708

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3751760/

Abstract

BACKGROUND

Few studies to date have evaluated gastric cancer(GC)-related malignant neoplasm family history (MN-FH), and their findings have been largely inconsistent. The aim of this study is to evaluate the prevalence of MN-FH and its relation to the clinicopathologic features of GC.

METHODS

A total of 104 hospitalized patients with primary gastric adenocarcinoma was prospectively analyzed from 2008 to 2009. Positive MN-FH was defined as MN-affected first- and second-degree relatives of the current GC cases. The relation between prevalence of positive MN-FH and clinicopathologic features in the current GC patients was assessed using the Chi-square test with Cramer's V coefficient.

RESULTS

Thirty-seven (35.6%) of the GC patients had positive MN-FH, with 42 associated tumors in first- and second-degree relatives. Twenty-six (61.9%) of the associated tumors were located in the digestive system, including the esophagus (26.2%), stomach (23.8%), liver (9.5%) and colon (2.4%). Lung cancers were the most prevalent non-digestive system-associated tumors (9.5%). Correlation analysis revealed no significant relations with prevalence of MN-FH and any of the clinicopathologic features (all, P > 0.05), including sex (V = 0.044), age (V = 0.060) and histological subtypes (V = 0.109).

CONCLUSIONS

More than one-third of the GC patients in our hospital had positive MN-FH. The most frequent forms of MN-FH were esophageal cancer and GC. The prevalence of positive MN-FH was not correlated to any of the clinicopathologic features, including sex, age and histological subtypes in the study population of GC patients.

摘要

背景

迄今为止，很少有研究评估胃癌（GC）相关恶性肿瘤家族史（MN-FH），其结果也大不相同。本研究旨在评估 MN-FH 的发生率及其与 GC 临床病理特征的关系。

方法

2008 年至 2009 年，前瞻性分析了 104 例原发性胃腺癌住院患者。MN-FH 阳性定义为当前 GC 病例的 MN 受累一级和二级亲属。采用卡方检验和 Cramer's V 系数评估当前 GC 患者中 MN-FH 阳性率与临床病理特征之间的关系。

结果

37 例（35.6%）GC 患者 MN-FH 阳性，一级和二级亲属中有 42 例相关肿瘤。26 例（61.9%）相关肿瘤位于消化系统，包括食管（26.2%）、胃（23.8%）、肝（9.5%）和结肠（2.4%）。肺癌是最常见的非消化系统相关肿瘤（9.5%）。相关性分析显示，MN-FH 阳性率与任何临床病理特征均无显著相关性（均 P > 0.05），包括性别（V = 0.044）、年龄（V = 0.060）和组织学亚型（V = 0.109）。