Kramer M W, Heinisch A, Wegener G, Abbas M, von Klot C, Peters I, Tezval H, Herrmann T R, Kuczyk M A, Merseburger A S
Klinik für Urologie und Urologische Onkologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland.
Urologe A. 2014 Feb;53(2):222-7. doi: 10.1007/s00120-013-3299-x.
Numerous studies have shown a positive correlation between elevated C-reactive protein (CRP) and systemic spread of malignancies. The goal of the current study was to assess the predictive significance of preoperative CRP in patients undergoing radical cystectomy (RC).
Preoperative CRP values were measured in 194 patients undergoing RC because of urothelial carcinoma between 1996 and 2005. Elevated CRP level was defined as ≥ 5 mg/l.
Preoperative increased CRP values were detected in 89 (45.9%) patients and these patients were more likely to have advanced tumor stages (pT3-4), positive resection margins and positive lymph nodes. Advanced urinary diversions were more common in patients with normal CRP values. In multivariate analysis, CRP was identified as an independent prognostic indicator for poor cancer-specific survival.
The results confirm previous reports that showed a prognostic significance of preoperative CRP elevation.
大量研究表明，C反应蛋白（CRP）升高与恶性肿瘤的全身扩散之间存在正相关。本研究的目的是评估术前CRP在接受根治性膀胱切除术（RC）患者中的预测意义。
对1996年至2005年间因尿路上皮癌接受RC的194例患者进行术前CRP值测定。CRP水平升高定义为≥5mg/l。
89例（45.9%）患者术前CRP值升高，这些患者更有可能出现肿瘤晚期（pT3-4）、切缘阳性和淋巴结阳性。CRP值正常的患者更常采用高级尿流改道术。多因素分析显示，CRP是癌症特异性生存率低的独立预后指标。
结果证实了先前的报道，即术前CRP升高具有预后意义。
