Yuk Hyeong Dong, Ku Ja Hyeon
Department of Urology, Seoul National University Hospital, Seoul, South Korea.
College of Medicine, Seoul National University, Seoul, South Korea.
Front Oncol. 2020 Aug 21;10:1473. doi: 10.3389/fonc.2020.01473. eCollection 2020.
Urothelial carcinoma (UC) can occur in various parts of the urinary tract and occurs in different stages and grades. The disease recurs frequently and is monitored through a series of invasive tests, such as cystoscopy or ureteroscopy, over the lifetime of an individual. Although many researchers have attempted to stratify the risks of UC, with the majority being based on cancer characteristics and host factors such as performance status, a risk classification system has yet to be fully developed. Cancer affects various parts of the body through the systemic immune response, including changes in hormones, the number and ratio of white blood cells and platelets, and C-reactive protein (CRP) or albumin levels under the influence of neuroendocrine metabolism, hematopoietic function, and protein and energy metabolism, respectively. Herein, we reviewed various systemic inflammatory response markers (SIRs) related to UC, including CRP, albumin-globulin ratio, albumin, Glasgow prognostic score (GPS), modified GPS, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio. Our aim was to summarize the role of various SIRs in the treatment of patients with UC.
尿路上皮癌（UC）可发生于尿路的各个部位，且存在不同的分期和分级。该疾病复发频繁，在个体的一生中需通过一系列侵入性检查进行监测，如膀胱镜检查或输尿管镜检查。尽管许多研究人员试图对UC的风险进行分层，其中大多数基于癌症特征和宿主因素（如体能状态），但风险分类系统尚未完全建立。癌症通过全身免疫反应影响身体的各个部位，包括激素变化、白细胞和血小板的数量及比例，以及分别受神经内分泌代谢、造血功能和蛋白质与能量代谢影响的C反应蛋白（CRP）或白蛋白水平。在此，我们综述了与UC相关的各种全身炎症反应标志物（SIRs），包括CRP、白蛋白-球蛋白比值、白蛋白、格拉斯哥预后评分（GPS）、改良GPS、中性粒细胞-淋巴细胞比值和血小板-淋巴细胞比值。我们的目的是总结各种SIRs在UC患者治疗中的作用。
