Ogawa Norihito, Iseki Hideaki, Tsunozaki Hidefumi, Hayashi Mikiko, Baba Hironobu, Matsuyama Takatoshi, Uetake Hiroyuki, Sugihara Kenichi
Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan,
Surg Today. 2014 Nov;44(11):2174-9. doi: 10.1007/s00595-013-0681-7. Epub 2013 Aug 20.
Desmoid tumors are benign fibroblastic neoplasms with no metastatic potential, but a propensity for local recurrence even after complete surgical resection. These lesions can develop at any site in the body, and commonly occur in the intra-abdominal area. Intra-abdominal desmoid tumors usually occur at the mesentery or retroperitoneum, and may morphologically mimic gastrointestinal stromal tumors (GISTs). Distinguishing between these tumors is important, because the therapies differ substantially, but is often difficult even with the use of CD117 staining. We herein report the cases of two patients with sporadic intra-abdominal desmoid tumors that were differentiated from GIST by immunohistological examination using beta-catenin and CD34. Desmoid tumors specifically express nuclear beta-catenin, and show no expression of CD34. We recommend staining for beta-catenin and CD34 when an intra-abdominal desmoid tumor is suspected.
硬纤维瘤是一种无转移潜能的良性纤维母细胞瘤，但即使在完全手术切除后仍有局部复发倾向。这些病变可发生于身体的任何部位，常见于腹腔内。腹腔内硬纤维瘤通常发生于肠系膜或腹膜后，形态上可能酷似胃肠道间质瘤（GIST）。区分这些肿瘤很重要，因为治疗方法有很大差异，但即便使用CD117染色往往也很难区分。我们在此报告两例散发性腹腔内硬纤维瘤患者的病例，通过使用β-连环蛋白和CD34进行免疫组织学检查与GIST相鉴别。硬纤维瘤特异性表达核β-连环蛋白，且不表达CD34。当怀疑为腹腔内硬纤维瘤时，我们建议进行β-连环蛋白和CD34染色。
