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布加综合征在孕期的首次临床表现。

First clinical manifestation of Brugada syndrome during pregnancy.

作者信息

Prochnau Dirk, Figulla Hans R, Surber Ralf

机构信息

Department of Internal Medicine I, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.

出版信息

Herzschrittmacherther Elektrophysiol. 2013 Sep;24(3):194-6. doi: 10.1007/s00399-013-0287-1. Epub 2013 Aug 17.

DOI:10.1007/s00399-013-0287-1
PMID:23955544
Abstract

The role of hormonal changes during pregnancy in Brugada syndrome is unknown. Only rare case reports of Brugada syndrome during pregnancy have been published. In this article, we describe a patient with first clinical manifestation of Brugada syndrome during pregnancy. The definitive diagnosis could only be achieved by drug challenge with ajmaline after childbirth because the spontaneous typical Brugada-like pattern was absent. Elevated hormone levels during pregnancy may increase the risk for arrhythmias in particular cases.

摘要

孕期激素变化在布加综合征中的作用尚不清楚。仅有罕见的孕期布加综合征病例报告发表。在本文中，我们描述了一名在孕期首次出现布加综合征临床表现的患者。由于产后未出现自发的典型布加样图形，仅通过使用阿义马林进行药物激发试验才得以确诊。孕期激素水平升高在特定情况下可能会增加心律失常的风险。

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本文引用的文献

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Int J Obstet Anesth. 2011 Apr;20(2):181-4. doi: 10.1016/j.ijoa.2010.10.006. Epub 2010 Dec 22.
2
Electrical storm in Brugada syndrome during pregnancy.妊娠期布加综合征中的电风暴
Pacing Clin Electrophysiol. 2011 Feb;34(2):e18-21. doi: 10.1111/j.1540-8159.2010.02740.x.
3
SCN5A channelopathies--an update on mutations and mechanisms.SCN5A通道病——突变与机制的最新进展
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Prog Biophys Mol Biol. 2008 Oct-Nov;98(2-3):120-36. doi: 10.1016/j.pbiomolbio.2008.10.005. Epub 2008 Nov 5.
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Risk stratification of individuals with the Brugada electrocardiogram: a meta-analysis.Brugada心电图个体的风险分层：一项荟萃分析。
J Cardiovasc Electrophysiol. 2006 Jun;17(6):577-83. doi: 10.1111/j.1540-8167.2006.00455.x.
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Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association.布加综合征：第二届共识会议报告：得到心律学会和欧洲心律协会认可。
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Heart rate variability in patients with Brugada syndrome in Thailand.泰国布加综合征患者的心率变异性
Eur Heart J. 2003 Oct;24(19):1771-8. doi: 10.1016/j.ehj.2003.06.005.
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