Song In-Uk, Kim Young-Do, Cho Hyun-Ji, Chung Sung-Woo
Department of Neurology, College of Medicine, The Catholic University of Korea, Korea.
Intern Med. 2013;52(16):1787-92. doi: 10.2169/internalmedicine.52.0474. Epub 2012 Mar 1.
High-sensitivity C-reactive protein (hs-CRP) is an extremely sensitive systemic marker of inflammation and tissue damage, and increased levels of hs-CRP are strongly associated with inflammatory reactions. Microglia-mediated neuroinflammation has been hypothesized to play an important role in the pathogenesis of idiopathic Parkinson's disease (PD). However, the clinical value of the hs-CRP level in patients with PD is poorly defined. Therefore, we conducted this study to analyze the differences in the hs-CRP levels in PD patients with and without dementia.
We examined 72 PD patients without dementia (PDwoD) and 45 PD patients with dementia (PDD), as well as 84 control subjects. We investigated the differences in the hs-CRP and fibrinogen levels between these three groups.
The mean hs-CRP and fibrinogen values were not significantly different between the PDwoD and PDD groups; however, these two groups had significantly higher mean hs-CRP and fibrinogen values than the control group.
It is known that inflammation plays a role in the pathogenesis of PD and dementia. However, based on the results of this study, we cautiously speculate that although neuroinflammation plays a role in the development of neurodegenerative diseases, including PD and dementia, it may be unrelated to the pathogenesis of dementia in patients with PD.
高敏C反应蛋白（hs-CRP）是炎症和组织损伤极其敏感的全身性标志物，hs-CRP水平升高与炎症反应密切相关。小胶质细胞介导的神经炎症被认为在特发性帕金森病（PD）的发病机制中起重要作用。然而，PD患者中hs-CRP水平的临床价值尚不明确。因此，我们开展本研究以分析有无痴呆的PD患者hs-CRP水平的差异。
我们检查了72例无痴呆的PD患者（PDwoD）、45例有痴呆的PD患者（PDD）以及84名对照者。我们调查了这三组之间hs-CRP和纤维蛋白原水平的差异。
PDwoD组和PDD组的平均hs-CRP和纤维蛋白原值无显著差异；然而，这两组的平均hs-CRP和纤维蛋白原值均显著高于对照组。
已知炎症在PD和痴呆的发病机制中起作用。然而，基于本研究结果，我们谨慎推测，尽管神经炎症在包括PD和痴呆在内的神经退行性疾病的发展中起作用，但它可能与PD患者痴呆的发病机制无关。
