Hwang Michael J, Wu Pei Ru, Chen Chih-Ming, Chen Chia-Yu, Chen Chih-Jung
Department of Surgical Pathology, Changhua Christian Hospital, 135 Nanxiao Street, Changhua, Taiwan, ROC.
Med Mol Morphol. 2014 Mar;47(1):57-61. doi: 10.1007/s00795-013-0051-y. Epub 2013 Aug 18.
Mammary analogue secretory carcinoma (MASC) is a recently described malignancy of the salivary glands characterized by an ETV6-NTRK3 (EN) fusion gene. Morphologically, MASC is sometimes difficult to distinguish from acinic cell carcinoma. Consequently, identifying the chromosomal translocation is essential for diagnosis. We present a case of parotid gland MASC in a 13-year-old boy. To the best of our knowledge, this is the youngest case reported in the literature. Histologic evaluation showed a tumor composed of microcysts, tubular structures, solid nests, or papillary architecture, with secretions within the lumens of the cysts or tubules. Immunohistochemically, tumor cells showed diffuse positive staining of S-100 protein, cytokeratin 19, and vimentin. ETV6 rearrangement was detected by fluorescence in situ hybridization and EN fusion transcripts were verified by reverse transcription (RT-PCR) assay.
乳腺样分泌性癌（MASC）是一种最近被描述的唾液腺恶性肿瘤，其特征是存在ETV6-NTRK3（EN）融合基因。在形态学上，MASC有时难以与腺泡细胞癌区分开来。因此，识别染色体易位对于诊断至关重要。我们报告了一例13岁男孩腮腺MASC的病例。据我们所知，这是文献中报道的最年轻病例。组织学评估显示肿瘤由微囊肿、管状结构、实性巢状或乳头状结构组成，囊肿或小管腔内有分泌物。免疫组织化学检查显示，肿瘤细胞S-100蛋白、细胞角蛋白19和波形蛋白呈弥漫性阳性染色。通过荧光原位杂交检测到ETV6重排，并通过逆转录（RT-PCR）分析验证了EN融合转录本。
