Centre for Public Health, Queen's University Belfast, Room 0017, Ground Floor, Belfast, Northern Ireland, UK,
Adv Exp Med Biol. 2014;791:103-16. doi: 10.1007/978-1-4614-7783-9_7.
Sperm DNA damage has been shown to be a valuable diagnostic and prognostic biomarker for male infertility and assisted reproductive treatment (ART) outcome. It is linked to every fertility checkpoint from reduced fertilization rates, lower embryo quality and pregnancy rates to higher rates of spontaneous miscarriage and childhood diseases. It is more robust than conventional semen parameters.The aim of this chapter is to provide an overview of current laboratory tests and relationships between sperm DNA damage and clinical outcomes. The conclusion is that sperm DNA damage is an important indicator of semen quality, and its routine use in the fertility clinic would improve ART success rates.
精子 DNA 损伤已被证明是男性不育和辅助生殖治疗 (ART) 结果的有价值的诊断和预后生物标志物。它与每个生育检查点都有关联，从降低受精率、降低胚胎质量和妊娠率到更高的自然流产率和儿童疾病率。它比传统的精液参数更可靠。本章的目的是提供当前实验室检测方法和精子 DNA 损伤与临床结果之间关系的概述。结论是，精子 DNA 损伤是精液质量的一个重要指标，在生育诊所常规使用它可以提高 ART 成功率。
