Proshliakova E V, Ugriumov M V, Manukhin B N
Ontogenez. 1990 May-Jun;21(3):307-10.
Development of serotoninergic system of rat hypothalamus has been studied. The level of its maturity was measured by specific absorption of 3H-serotonin by hypothalamus of fetuses (days 16-20 of intra-uterine development), newborn (9 days after birth) and adult rats. Inhibitors of specific serotonin capture by serotoninergic neural elements (cocaine, fluoxetin and cytalopram) were used in control experiments. Specific uptake of 3H-serotonin by hypothalamus was detected on day 16 of intra-uterine development. It increased twice by day 18 and remained unchanged until birth. No statistically significant increase of 3H-serotonin uptake was detected in newborn and adult animals.
对大鼠下丘脑5-羟色胺能系统的发育进行了研究。通过胎儿（子宫内发育第16 - 20天）、新生大鼠（出生后9天）和成年大鼠下丘脑对3H-5-羟色胺的特异性摄取来衡量其成熟水平。在对照实验中使用了5-羟色胺能神经元对5-羟色胺特异性摄取的抑制剂（可卡因、氟西汀和西酞普兰）。子宫内发育第16天检测到下丘脑对3H-5-羟色胺的特异性摄取。到第18天增加了两倍，直至出生时保持不变。在新生和成年动物中未检测到3H-5-羟色胺摄取有统计学显著增加。
