Borisova N A, Proshliakova E V, Sapronova A Ia, Ugriumov M V
Biull Eksp Biol Med. 1992 Jun;113(6):653-5.
With the use of "isotopic method" a study was made of the main parameters of functional activity of serotoninergic elements of hypothalamus--the specific uptake and release of 5-OT. The animals used were sexually mature rats castrated on the first postnatal day. In sexually mature intact males the specific uptake of 3H-5-OT by serotoninergic structures of the anterior hypothalamus was significantly lower than in females. Castration of animals on the first day of life resulted in the increase of specific 5-OT uptake in sexually mature males up to that observed in females. There were no differences between the sexes in the rate of spontaneous release of 5-OT. However, response to K(+)-depolarization in the anterior hypothalamus of intact males was significantly lower than that in females. In the hypothalamus of males castrated neonatally the amplitude of the response to the effect of the depolarizing agent was increase up to the level observed in females. By the results obtained it is indicated that elimination of the effect of male hormones on the first postnatal day results in the increase of 5-OT uptake and release in the hypothalamus of sexually mature rat males.
运用“同位素法”对下丘脑5-羟色胺能神经元功能活动的主要参数——5-羟色胺（5-OT）的特异性摄取和释放进行了研究。所用动物为出生后第一天阉割的性成熟大鼠。在性成熟的未阉割雄性大鼠中，下丘脑前部5-羟色胺能结构对3H-5-OT的特异性摄取显著低于雌性大鼠。出生第一天对动物进行阉割，会使性成熟雄性大鼠的5-OT特异性摄取增加至雌性大鼠的水平。5-羟色胺（5-OT）的自发释放速率在两性之间并无差异。然而，未阉割雄性大鼠下丘脑前部对K(+)去极化的反应显著低于雌性大鼠。在新生期阉割的雄性大鼠下丘脑中，对去极化剂作用的反应幅度增加至雌性大鼠的水平。根据所得结果表明，出生后第一天消除雄性激素的影响会导致性成熟雄性大鼠下丘脑对5-OT的摄取和释放增加。
