基于纳米粒子-酶相互作用和分子印迹的选择性人工酶抑制剂。
A selective artificial enzyme inhibitor based on nanoparticle-enzyme interactions and molecular imprinting.
机构信息
The Key Lab of Analysis Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350108, P. R. China.
出版信息
Adv Mater. 2013 Nov 6;25(41):5922-7. doi: 10.1002/adma.201302064. Epub 2013 Aug 19.
A novel and general strategy is developed to design selective artificial enzyme inhibitor based on nanoparticleenzyme inter actions and molecular imprinting. Due to the creation of specific binding cavities, the resulting artificial inhibitor has high inhibition efficiency for the target enzyme, and shows great target-selectivity over other enzymes of similar function and proteins of compaable mole cular weight.
发展了一种新颖且通用的策略，基于纳米酶相互作用和分子印迹来设计选择性人工酶抑制剂。由于特定结合腔的创建，所得的人工抑制剂对靶酶具有高抑制效率，并对具有相似功能的其他酶和具有相似分子量的蛋白质表现出出色的靶选择性。
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