骨肉瘤患儿大剂量甲氨蝶呤致过敏反应及再次用药成功。
Hypersensitivity reaction to high-dose methotrexate and successful rechallenge in a pediatric patient with osteosarcoma.
机构信息
Pharmaceutical Department, St. Jude Children's Research Hospital, Memphis, Tennessee.
出版信息
Pediatr Blood Cancer. 2014 Feb;61(2):373-5. doi: 10.1002/pbc.24741. Epub 2013 Aug 19.
Abstract
Hypersensitivity reactions to methotrexate are rare, but have been reported. Methotrexate has shown activity against many malignancies, and omission of methotrexate therapy may increase the risk of cancer-related death in some patients. Therefore, rechallenging patients with methotrexate following hypersensitivity may be beneficial. We report a case of a child with metastatic osteosarcoma who experienced a hypersensitivity reaction to high-dose methotrexate and was successfully rechallenged with methotrexate using a 6-hour infusion. Using this regimen, adequate peak methotrexate plasma concentrations were achieved and no further hypersensitivity reactions were noted.
摘要
甲氨蝶呤过敏反应罕见，但已有报道。甲氨蝶呤对许多恶性肿瘤均具有活性，如果停止使用甲氨蝶呤治疗，可能会增加某些患者因癌症相关死亡的风险。因此，对发生甲氨蝶呤过敏反应的患者再次使用甲氨蝶呤可能有益。我们报告了一例患有骨肉瘤转移的儿童，该患儿在接受大剂量甲氨蝶呤治疗时发生过敏反应，随后采用 6 小时输注的方式成功再次使用甲氨蝶呤进行治疗。采用该方案可达到足够的甲氨蝶呤血浆峰浓度，且未再出现过敏反应。
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