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1
Desensitizations for chemotherapy and monoclonal antibodies: indications and outcomes.化疗和单克隆抗体脱敏：适应证和结局。
Curr Allergy Asthma Rep. 2014 Aug;14(8):453. doi: 10.1007/s11882-014-0453-5.
2
Rapid drug desensitization for hypersensitivity reactions to chemotherapy and monoclonal antibodies in the 21st century.21 世纪化疗和单克隆抗体药物过敏反应的快速药物脱敏治疗。
J Investig Allergol Clin Immunol. 2014;24(2):72-9; quiz 2 p following 79.
3
Indications, protocols, and outcomes of drug desensitizations for chemotherapy and monoclonal antibodies in adults and children.成人和儿童中化疗和单克隆抗体药物脱敏的适应证、方案和结局。
J Allergy Clin Immunol Pract. 2014 Jan-Feb;2(1):13-9; quiz 20. doi: 10.1016/j.jaip.2013.11.007.
4
Hypersensitivity reaction to high-dose methotrexate and successful rechallenge in a pediatric patient with osteosarcoma.骨肉瘤患儿大剂量甲氨蝶呤致过敏反应及再次用药成功。
Pediatr Blood Cancer. 2014 Feb;61(2):373-5. doi: 10.1002/pbc.24741. Epub 2013 Aug 19.
5
Incidence, clinical features and management of hypersensitivity reactions to chemotherapeutic drugs in children with cancer.儿童癌症患者化疗药物过敏反应的发生率、临床特征及处理。
Eur J Clin Pharmacol. 2013 Oct;69(10):1739-46. doi: 10.1007/s00228-013-1546-0. Epub 2013 Jun 14.
6
Successful desensitization to low-dose methotrexate.
Rheumatology (Oxford). 2013 Dec;52(12):2305-6. doi: 10.1093/rheumatology/ket183. Epub 2013 May 16.
7
Desensitization for hypersensitivity reactions to medications.药物超敏反应的脱敏治疗。
Chem Immunol Allergy. 2012;97:217-33. doi: 10.1159/000335637. Epub 2012 May 3.
8
Anaphylaxis during the first course of high-dose methotrexate: a case report and literature review.大剂量甲氨蝶呤治疗首程中发生过敏反应：1 例病例报告并文献复习。
J Clin Pharm Ther. 2012 Apr;37(2):245-8. doi: 10.1111/j.1365-2710.2011.01275.x. Epub 2011 May 13.
9
General considerations on rapid desensitization for drug hypersensitivity - a consensus statement.关于药物过敏快速脱敏的一般考虑——共识声明。
Allergy. 2010 Nov;65(11):1357-66. doi: 10.1111/j.1398-9995.2010.02441.x. Epub 2010 Aug 17.
10
Anaphylactoid reaction to high-dose methotrexate and successful desensitization.甲氨蝶呤高剂量治疗引发过敏样反应及脱敏治疗成功
Pediatr Blood Cancer. 2010 Sep;55(3):557-9. doi: 10.1002/pbc.22616.

儿科甲氨蝶呤超敏反应：评估与管理

Methotrexate hypersensitivity reactions in pediatrics: Evaluation and management.

作者信息

Dilley Meredith A, Lee Joyce P, Broyles Ana Dioun

机构信息

Division of Immunology at Boston Children's Hospital, Boston, Massachusetts.

Department of Pharmacy at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

出版信息

Pediatr Blood Cancer. 2017 May;64(5). doi: 10.1002/pbc.26306. Epub 2016 Oct 27.

DOI:10.1002/pbc.26306
PMID:27786403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5366073/
Abstract

Reports of hypersensitivity reactions (HSRs) to MTX are limited to single case studies. We retrospectively reviewed HSRs to MTX during a 12-year period in our tertiary care pediatric center. Seven patients were evaluated for HSRs to MTX. Skin testing was positive in one of the four patients tested. One patient underwent successful graded challenge to MTX. Seventeen desensitizations to MTX were successfully performed in the other six patients. Skin testing, graded challenge, and desensitization were safe and effective procedures in the evaluation and management of patients with HSRs to MTX in our pediatric population.

摘要

关于甲氨蝶呤（MTX）过敏反应（HSRs）的报告仅限于单个病例研究。我们回顾性地研究了在我们三级护理儿科中心12年期间对MTX的过敏反应。对7例患者进行了MTX过敏反应评估。4例接受检测的患者中有1例皮肤试验呈阳性。1例患者成功进行了MTX分级激发试验。另外6例患者成功进行了17次MTX脱敏治疗。在我们儿科人群中，皮肤试验、分级激发试验和脱敏治疗是评估和管理MTX过敏反应患者的安全有效的方法。