蓝莓可预防间歇性低压低氧对大鼠附睾的影响。

Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis.

作者信息

Zepeda A B, Calaf G M, Figueroa C A, Farías J G

机构信息

Departamento de Ingeniería Química, Facultad de Ingeniería, Ciencias y Administración, Universidad de La Frontera, Temuco, Chile.

出版信息

Andrologia. 2014 Sep;46(7):766-9. doi: 10.1111/and.12146. Epub 2013 Aug 19.

DOI:10.1111/and.12146

PMID:23957290

Abstract

Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry-enriched polyphenol extract (BB-4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whether BB-4 could reverse oxidative stress in epididymis. To evaluate the protective role of BB-4 in epididymis, male rats were exposed to IHH. Lipid peroxidation, (LPO) expression and activity of glutathione reductase (GR) were evaluated. Our results showed a reduction in LPO and a decrease in GR activity in rat epididymis exposed to IHH. These results suggest that BB-4 can prevent the effects of IHH in rat epididymis.

摘要

间歇性低压低氧（IHH）导致精子数量减少以及附睾氧化损伤。我们之前已经证明，富含蓝莓的多酚提取物（BB - 4）可减轻低压低氧条件下大鼠睾丸氧化应激的不良影响。本研究的目的是评估BB - 4是否能逆转附睾中的氧化应激。为了评估BB - 4在附睾中的保护作用，将雄性大鼠暴露于IHH环境中。评估了脂质过氧化（LPO）、谷胱甘肽还原酶（GR）的表达和活性。我们的结果显示，暴露于IHH的大鼠附睾中LPO降低，GR活性下降。这些结果表明，BB - 4可以预防IHH对大鼠附睾的影响。