Pires Vanessa Cardoso, Anacleto Sara Lima, Matté Cristiane, Aguiar Odair, Lajolo Franco Maria, Hassimotto Neuza Mariko Aymoto, Ong Thomas Prates
Department of Food Science, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Department of Biochemistry, Institute of Fundamental Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, Brazil.
Antioxidants (Basel). 2025 Jun 25;14(7):779. doi: 10.3390/antiox14070779.
Dietary polyphenols' role in early life is not clear. While accumulating studies show both beneficial and deleterious effects of maternal consumption of these bioactive compounds on offspring's adult health, very few studies have focused on the impact of paternal consumption. In addition, the potential interaction of combined parental polyphenol consumption is still not known. Thus, the aim of the present study was to investigate the effects of maternal (gestation/lactation) and/or paternal (preconception) blackberry polyphenol (anthocyanins, ellagitannins, and quercetin) methanolic extract consumption on C57BL/6 female mice offspring. Blackberry polyphenol consumption by fathers improved their sperm production and increased fertility. Blackberry polyphenol consumption by fathers, but not mothers, increased their plasma antioxidant capacity. All parental interventions decreased offspring perinatal mortality, with combined fathers' and mothers' polyphenol consumption exerting the most pronounced effects. Paternal or maternal polyphenol consumption decreased plasma total antioxidant capacity in the female offspring. On the other hand, combined parental consumption had opposing effects on the offspring. Only maternal polyphenol interventions increased glucose tolerance in the female offspring. These data only partially confirm our hypothesis that combined paternal and maternal polyphenol intervention would lead to better outcomes in the offspring. These results further show that blackberry polyphenols' effects on offspring health depend on whether their consumption occurred through the father, mother, or both. This suggests that in order to promote long-term health in descendants, nutritional interventions, including those with polyphenols, should target not only the mother but also the future father.
膳食多酚在生命早期的作用尚不清楚。虽然越来越多的研究表明母体摄入这些生物活性化合物对后代成年后的健康既有有益影响也有有害影响，但很少有研究关注父体摄入的影响。此外，父母双方联合摄入多酚的潜在相互作用仍不清楚。因此，本研究的目的是调查母体（妊娠期/哺乳期）和/或父体（受孕前）食用黑莓多酚（花青素、鞣花单宁和槲皮素）甲醇提取物对C57BL/6雌性小鼠后代的影响。父体食用黑莓多酚可改善精子生成并提高生育能力。父体而非母体食用黑莓多酚可提高其血浆抗氧化能力。所有的亲代干预都降低了后代围产期死亡率，父母双方联合食用多酚的效果最为显著。父体或母体食用多酚会降低雌性后代的血浆总抗氧化能力。另一方面，父母双方联合食用对后代有相反的影响。只有母体多酚干预提高了雌性后代的葡萄糖耐量。这些数据仅部分证实了我们的假设，即父母双方联合进行多酚干预会使后代有更好的结果。这些结果进一步表明，黑莓多酚对后代健康的影响取决于其食用是通过父体、母体还是双方。这表明，为了促进后代的长期健康,营养干预措施，包括那些使用多酚的措施，不仅应针对母亲，还应针对未来的父亲。
