钯催化含β-氟的偕丙醇的反马氏羟烷基化反应。
Palladium-catalyzed anti-Markovnikov hydroalkylation of homoallylic alcohols bearing β-fluorines.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
出版信息
Org Lett. 2013 Sep 6;15(17):4478-81. doi: 10.1021/ol402032a. Epub 2013 Aug 19.
PMID:23957347
Abstract
A palladium-catalyzed anti-Markovnikov hydroalkylation of β,β-difluorinated homoallylic alcohols with alkylzinc reagents has been developed. This method affords a wide range of synthetically useful gem-difluorinated compounds with good functional group compatibility.
摘要
钯催化的β,β-二氟代偕同烯丙醇与烷基锌试剂的反马氏羟烷基化反应已被开发。该方法提供了广泛的具有良好官能团兼容性的合成有用的偕二氟代化合物。
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