Ru Yongxin, Zhang Peihong, Dong Shuxu, Wang Huijun, Zhao Shixuan, Mi Yingchang, Eyden Brian
Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , China and.
Ultrastruct Pathol. 2014 Feb;38(1):66-8. doi: 10.3109/01913123.2013.813998. Epub 2013 Aug 19.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive lymphoma derived from plasmacytoid dendritic cells or precursor dendritic cells. Despite some 240 reported cases, its morphology and especially ultrastructure has not been satisfactorily studied. A case is reported of a 13 year old boy, who, despite chemotherapy, died within a 12-month period. The electron microscopy findings - microvillous processes, nuclei with slight irregularities, a moderate amount of heterochromatin, and rough endoplasmic reticulum in the form of long, narrow profiles, often in parallel arrangements - taken together, serve to distinguish BPDCN from other neoplastic cells, such as monocytes, plasma cells and the cells of chronic lymphocyte leukemia.
母细胞性浆细胞样树突状细胞肿瘤（BPDCN）是一种罕见的侵袭性淋巴瘤，起源于浆细胞样树突状细胞或前体树突状细胞。尽管已有约240例报道病例，但其形态，尤其是超微结构尚未得到充分研究。本文报告了一例13岁男孩的病例，该男孩尽管接受了化疗，但仍在12个月内死亡。电镜检查结果——微绒毛状突起、核稍有不规则、中等量异染色质以及呈长而窄的形态、常呈平行排列的粗面内质网——综合起来有助于将BPDCN与其他肿瘤细胞，如单核细胞、浆细胞和慢性淋巴细胞白血病细胞区分开来。
