Marek E, Dergez T, D'cruz G, Bozsa S, Cseh A, Szilard I, Benczik M, Kiss I, Varszegi D, Vilagi S, Ember I, Gocze P
Medical School, University of Pecs, Pecs, Hungary.
Eur J Cancer Care (Engl). 2014 Jan;23(1):65-75. doi: 10.1111/ecc.12110. Epub 2013 Aug 19.
The purpose of this study was to assess the human papillomavirus (HPV) prevalence in cervical, oropharyngeal and anal samples of the high-risk population of Hungarian female sex workers (FSWs). HPV testing of swab specimens from FSWs (n = 34) using polymerase chain reaction (PCR) methodology was performed. Results were compared with control group (n = 52) matched for age. Questionnaires were used to obtain data regarding participants' sexual behaviour. Data were analysed using SPSS. HPV DNA was detected in at least one location in a great majority of FSWs (82.4%), compared with 46.2% of the general female population (P < 0.05). Both the cervical and the anal samples of sex workers showed higher infection rates than those of controls (64.7% vs. 34.6% and 50.0% vs. 15.4%, respectively, P < 0.05). High-risk HPV prevalence was also significantly higher in sex workers (55.9% vs. 25.0%, P < 0.05). A significantly higher proportion of FSWs had a history of genital warts (26.5% vs. 3.8%, P < 0.05). The results suggest that condom use may not result in adequate protection from HPV infection. The high infection rates among FSWs should be viewed as a priority group for HPV and cervical cancer prevention programmes since they are sources of HPV infection for the general population.
本研究的目的是评估匈牙利女性性工作者（FSW）高危人群宫颈、口咽和肛门样本中的人乳头瘤病毒（HPV）流行情况。使用聚合酶链反应（PCR）方法对FSW（n = 34）的拭子标本进行HPV检测。将结果与年龄匹配的对照组（n = 52）进行比较。通过问卷调查获取参与者性行为的数据。使用SPSS对数据进行分析。绝大多数FSW（82.4%）至少在一个部位检测到HPV DNA，而普通女性人群的这一比例为46.2%（P < 0.05）。性工作者的宫颈和肛门样本感染率均高于对照组（分别为64.7%对34.6%和50.0%对15.4%，P < 0.05）。高危型HPV的流行率在性工作者中也显著更高（55.9%对25.0%，P < 0.05）。有生殖器疣病史的FSW比例显著更高（26.5%对3.8%，P < 0.05）。结果表明，使用避孕套可能无法充分预防HPV感染。FSW中的高感染率应被视为HPV和宫颈癌预防项目的优先群体，因为她们是普通人群HPV感染的来源。
